Molecular detection of colistin resistance genes (mcr-1 to mcr-5) in human vaginal swabs

BMC Research Notes
Jilei ZhangChengming Wang

Abstract

Colistin resistance has emerged worldwide and has been threatening the efficacy of one of the last-resort antimicrobials used for treatment of multidrug resistant Gram-negative bacteria. While five colistin resistance genes (mcr-1, mcr-2, mcr-3, mcr-4 and mcr-5) have been described, few data are available on the prevalence of mcr-genes other than mcr-1 in human samples. In this study, the presence of five currently described colistin resistance genes (mcr 1-5) in vaginal swabs of women undergoing infertility evaluation was reported. Most samples were found to be positive for the mcr-4 (12.7%), followed by two for the mcr-2 (1.5%), two for the mcr-3 (1.5%), one for the mcr-1 (0.7%), and one for the mcr-5 (0.7%). Phylogenetic comparison demonstrated identical (mcr-1, mcr-2, mcr-3, mcr-5) or similar (mcr-4) nucleotide sequences of human samples and those of animal origins from the same city, suggesting the potential transmission of mcr genes from animals to humans. This is the first detection of mcr-2, mcr-4 and mcr-5 genes in human samples, and warrants further research to determine the spread of the mcr genes and elucidate the full epidemiology of colistin resistance genes in humans.

References

Jul 16, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Basil Britto XavierSurbhi Malhotra-Kumar
Mar 21, 2017·Antimicrobial Resistance and Infection Control·Katrin ZurfluhMagdalena Nüesch-Inderbinen
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Citations

Sep 12, 2018·The Journal of Antimicrobial Chemotherapy·Miriam R FernandesNilton Lincopan
Sep 24, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Polly Soo Xi YapCindy Shuan Ju Teh
Apr 15, 2020·Emerging Microbes & Infections·Mohamed Abd El-Gawad El-Sayed AhmedGuo-Bao Tian
May 28, 2019·Critical Reviews in Microbiology·Sue C NangTony Velkov
Jul 11, 2018·Antimicrobial Agents and Chemotherapy·Hui LiYang Wang
Oct 19, 2019·Environmental Science and Pollution Research International·Firdoos Ahmad GogryQazi Mohd Rizwanul Haq
Jun 10, 2020·The Journal of Antimicrobial Chemotherapy·Zhuoren LingTimothy R Walsh
Nov 12, 2020·Animals : an Open Access Journal From MDPI·Sayara BistaPrakash Ghimire
Aug 8, 2021·The Science of the Total Environment·Shaqiu ZhangAnchun Cheng
Apr 6, 2021·Deutsches Ärzteblatt International·Robin KöckBirgit Walther

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Methods Mentioned

BETA
PCRs
PCR

Software Mentioned

Clustal Multiple Alignment Algorithm
BLASTN
MEGA

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

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