Molecular determinants of occult metastatic tumor cells in bone marrow

Clinical Breast Cancer
Klaus Pantel, S Braun

Abstract

The success of mammographic screening for breast cancer is that it involves increasingly more patients with small primary tumors formerly thought to have an overall excellent prognosis. Yet, only approximately two thirds of these patients actually have this favorable prognosis, while the remaining third develops metastatic disease. Thus, there is emerging evidence that epithelial tumor cells can disseminate into secondary organs at an earlier stage of primary tumor development than appreciated by current risk classifications. Bone marrow is one of the most prominent secondary organs screened for the presence of disseminated tumor cells. The current data suggest that bone marrow micrometastases represent a selected population of dormant and heterogeneous cancer cells. The analysis of micrometastatic cells opens a new avenue by which to assess the molecular determinants of both early tumor cell dissemination and subsequent outgrowth into overt metastases. Moreover, identifying therapeutic target structures (e.g., HER2/neu), monitoring the elimination of bone marrow micrometastases, and assessing treatment-resistant tumor cell clones might help to understand the current limitations of adjuvant systemic therapy. This review summari...Continue Reading

References

Oct 1, 1992·Current Opinion in Immunology·G Riethmüller, J P Johnson
Jun 1, 1992·Seminars in Cell Biology·J BehrensW Birchmeier
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J BartekJ Taylor-Papadimitriou
May 1, 1991·Journal of Surgical Oncology·S E SingletaryG Spitzer
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B SalvadoriM I Colnaghi
Jan 1, 1990·Annual Review of Cell Biology·M A SchwarzW W Franke
Jan 1, 1990·Breast Cancer Research and Treatment·M C MathieuG Contesso
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G SchlimokG Riethmüller
Jul 28, 1989·Biochimica Et Biophysica Acta·I R HartR E Wilson
Aug 2, 1995·Journal of the National Cancer Institute·K PantelE Fanning
Sep 1, 1993·Journal of the National Cancer Institute·K PantelG Riethmüller
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G SchlimokG Riethmüller
Mar 15, 1996·International Journal of Cancer. Journal International Du Cancer·I FunkeK W Jauch
Jan 1, 1996·Progress in Histochemistry and Cytochemistry·K PantelG Schlimok
Aug 1, 1996·Journal of Hematotherapy·K Pantel
May 16, 1997·International Journal of Cancer. Journal International Du Cancer·K PantelM W Köllermann
Jul 16, 1997·Journal of the National Cancer Institute·S B FoxA L Harris
Jun 17, 1998·International Journal of Cancer. Journal International Du Cancer·B BrandtK S Zänker
Feb 13, 1999·International Journal of Cancer. Journal International Du Cancer·S BraunK Pantel
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·C A KleinG Riethmüller

❮ Previous
Next ❯

Citations

May 31, 2008·Surgical Oncology·Pauline Athanassiadou, Dimitra Grapsa
Oct 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lyndsay HarrisUNKNOWN American Society of Clinical Oncology
Dec 22, 2006·Nature Clinical Practice. Oncology·Martin J Slade, R Charles Coombes
May 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rainer GangnusMichael R Speicher
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Saltanat NajmiRobert Wieder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.