Molecular determinants of radiation response in non-small cell lung cancer

Seminars in Radiation Oncology
Sue S YomDavid Raben

Abstract

Non-small cell lung cancers are now recognized to contain considerable heterogeneity and molecular diversity. Substantial progress has been made regarding molecular determinants of response to targeted agents in advanced lung cancer, and recent findings have revealed subsets of patients with driver mutations that respond rapidly to selective inhibitors. In addition, new approaches to disrupting DNA repair and inflammation and activation of the immune system are being explored. A key question in the field is whether therapeutic multimodality options incorporating radiation therapy can capitalize on the gains made in systemic therapy.

References

Dec 3, 1999·Science·T Lindahl, R D Wood
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Feb 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Sandra DemariaSilvia C Formenti
Jun 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul OkunieffLynn H Gerber
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
Nov 16, 2004·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sylvie Delanian, Jean-Louis Lefaix
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kaye J WilliamsStephen R Wedge
Jun 9, 2005·Oncogene·Eric T ShinoharaBo Lu
Oct 18, 2005·Molecular and Cellular Biology·Richard V ParryJames L Riley
Mar 31, 2007·Seminars in Radiation Oncology·John E Moulder, Eric P Cohen
May 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeffrey M AlbertBo Lu
Jul 25, 2007·Cancer Science·Masanao Miwa, Mitsuko Masutani
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alfredo A MolinoloJ Silvio Gutkind
Apr 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amit KumarTitus J Boggon
Aug 19, 2008·Genes, Chromosomes & Cancer·Patrick C MaRavi Salgia
Jan 17, 2009·The American Journal of Pathology·Maria Paola MartelliBrunangelo Falini
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shivaani KummarJames H Doroshow
May 12, 2009·Immunological Reviews·Christopher E RuddHelga Schneider
Jun 26, 2009·The New England Journal of Medicine·Peter C FongJohann S de Bono
Mar 5, 2010·Nature Reviews. Cancer·Michèle RouleauGuy G Poirier
May 4, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Dirk RadesFrank Noack
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Aug 6, 2010·Seminars in Radiation Oncology·Amit K DasJohn D Minna
Sep 14, 2010·Seminars in Radiation Oncology·Anthony J ChalmersRobert G Bristow
Dec 15, 2010·Nature Reviews. Clinical Oncology·Naoko TakebeS Percy Ivy
Mar 2, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christine H ChungK Kian Ang
Jun 7, 2011·The New England Journal of Medicine·Caroline RobertJedd D Wolchok
Feb 1, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anand G PatelScott H Kaufmann
Mar 1, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arun RajanGiuseppe Giaccone
Mar 6, 2012·Seminars in Radiation Oncology·Thomas B BrunnerMichael Baumann
Mar 9, 2012·The New England Journal of Medicine·Michael A PostowJedd D Wolchok
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
May 9, 2012·International Journal of Radiation Oncology, Biology, Physics·Emily F StamellIsaac Brownell

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Citations

Apr 24, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F CouñagoN Rodríguez de Dios
Jun 28, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jonathan KhalifaUNKNOWN International Association for the Study of Lung Cancer Advanced Radiation Technology Committee
Mar 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Elena Arechaga-OcampoAlejandro Garcia-Carranca

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