Molecular Determinants of Target Cell Recognition by Human γδ T Cells

Frontiers in Immunology
André E SimõesBruno Silva-Santos

Abstract

The unique capabilities of gamma-delta (γδ) T cells to recognize cells under stressed conditions, particularly infected or transformed cells, and killing them or regulating the immune response against them, paved the way to the development of promising therapeutic strategies for cancer and infectious diseases. From a mechanistic standpoint, numerous studies have unveiled a remarkable flexibility of γδ T cells in employing their T cell receptor and/or NK cell receptors for target cell recognition, even if the relevant ligands often remain uncertain. Here, we review the accumulated knowledge on the diverse mechanisms of target cell recognition by γδ T cells, focusing on human γδ T cells, to provide an integrated perspective of their therapeutic potential in cancer and infectious diseases.

References

Apr 1, 1995·European Journal of Immunology·G SchuhmachersA Takashima
Feb 1, 1993·Seminars in Immunology·C J Rust, F Koning
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·T HaraK Takeshita
Aug 1, 1997·Immunology·J L YoungJ S Gaston
Feb 27, 1999·International Journal of Cancer. Journal International Du Cancer·A D LaadS V Chiplunkar
Mar 6, 1999·The New England Journal of Medicine·V KunzmannM Wilhelm
Jun 8, 1999·European Journal of Immunology·H NakajimaM Colonna
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·V GrohT Spies
May 30, 2002·Nature Reviews. Immunology·Simon R Carding, Paul J Egan
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer WuThomas Spies
Jan 23, 2003·The Journal of Experimental Medicine·Hans-Jürgen GoberGennaro De Libero
Apr 15, 2003·The Journal of General Virology·Karen BiebackSibylle Schneider-Schaulies
Jun 5, 2003·FEBS Letters·Matthias EberlHassan Jomaa
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen C De RosaMario Roederer
Mar 22, 2005·Microbes and Infection·Fabrizio PocciaMiroslav Malkovsky
Feb 13, 2007·Immunological Reviews·Aurélie ThedrezMarc Bonneville
Mar 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna M RussanoFabrizio Spinozzi
May 1, 2009·European Journal of Immunology·Olivier ToutiraisVéronique Catros
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matilde TodaroGiorgio Stassi
Jun 17, 2009·The Journal of Experimental Medicine·Cameron S BrandtSteven D Levin
Feb 9, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Jun NakajimaKazuhiro Kakimi

❮ Previous
Next ❯

Citations

Sep 25, 2019·Microorganisms·Eleonora CiminiChiara Agrati
Sep 8, 2019·Nature Reviews. Drug Discovery·Zsolt SebestyenJurgen Kuball
Oct 10, 2018·Frontiers in Oncology·Georg Gruenbacher, Martin Thurnher
Jul 6, 2019·Scientific Data·Biagio Di LorenzoBruno Silva-Santos
Oct 6, 2020·Frontiers in Immunology·Rulan MaKang Li
Nov 24, 2018·Blood·Meixiao Long
Nov 21, 2018·Frontiers in Immunology·Manuela Del CornòSandra Gessani
Mar 12, 2020·Immune Network·Hye Won LeeTae Jin Kim
Jun 9, 2020·Frontiers in Cellular and Infection Microbiology·Jennifer A Juno, Stephen J Kent
Jul 24, 2020·Cellular & Molecular Immunology·Dieter KabelitzShirin Kalyan
Jun 19, 2019·Nature Reviews. Cancer·Bruno Silva-SantosSeth B Coffelt
Oct 6, 2020·Immunological Reviews·Adam P UldrichDale I Godfrey
Oct 23, 2020·Immunological Reviews·Hannah KaminskiLionel Couzi
Mar 22, 2019·Cancer Immunology Research·Biagio Di LorenzoBruno Silva-Santos
Nov 17, 2020·Frontiers in Immunology·Jin WoGuodong Sun
Jan 19, 2021·Oncoimmunology·Adeline RaynaudBrigitte Kerfelec
Jan 29, 2021·Journal of Immunology Research·Nilberto Dias de AraújoAllyson Guimarães Costa
Jun 15, 2021·Frontiers in Immunology·Hong LiuAi-Hua Liao
Jun 27, 2021·Proceedings of the National Academy of Sciences of the United States of America·Robert J MallisEllis L Reinherz
Jul 13, 2021·Frontiers in Immunology·UNKNOWN Frontiers Production Office
Aug 1, 2021·American Journal of Reproductive Immunology : AJRI·Qian-Han XuAi-Hua Liao
Aug 28, 2021·Nature Reviews. Nephrology·Hannah KaminskiMatthias Eberl
Oct 26, 2021·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sarka VanikovaJan Musil

❮ Previous
Next ❯

Methods Mentioned

BETA
xenograft

Software Mentioned

Lymphact

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Immunology and Immunopathology
R Boismenu, W L Havran
Microbiology and Immunology
Yasunobu Yoshikai
Proceedings of the National Academy of Sciences of the United States of America
O MandelboimJ L Strominger
© 2022 Meta ULC. All rights reserved