Molecular diagnosis and classification of inflammatory bowel disease

Expert Review of Molecular Diagnostics
Hu ZhangBo Shen

Abstract

Traditional diagnosis and classification of inflammatory bowel diseases (IBDs) have been based on clinical evaluation, laboratory testing, endoscopy, imaging, and histological examinations. With the advancement of medical technology, an increasing number of molecular surrogates are playing a key role in diagnosis, differential diagnosis, assessment of disease activity, prediction of clinical course, and therapeutic response of IBD. Areas covered: The authors review roles of both existing and emerging surrogates including genetic, serological, histologic, and fecal markers in diagnosis and classification of IBD. Comparisons in advantages and disadvantages of different markers have also been discussed. In addition, this review underscores controversial and unclear aspects which need further study. Expert commentary: IBD is characteristic of chronicity, relapse-remission and destructiveness. It is of great importance for clinicians to make an accurate diagnosis and classification. Current and new molecular markers perform well with acceptable sensitivity and specificity. The use of molecular markers in clinical practice needs to be further explored and then generalized. More work is warranted to identify novel useful markers and e...Continue Reading

References

Sep 1, 1992·Scandinavian Journal of Gastroenterology·A G RøsethH Schjønsby
Oct 29, 1988·BMJ : British Medical Journal·J MainD Parratt
Nov 1, 1973·Acta Medica Scandinavica·R BerlinO Vikrot
Sep 1, 1969·The Journal of Experimental Medicine·P L MassonE Schonne
Jan 1, 1969·Scandinavian Journal of Haematology·H HeistöB Uggerud
Aug 1, 1982·European Journal of Clinical Investigation·E A FaganM B Pepys
Sep 1, 1993·Digestive Diseases and Sciences·T AndusJ Schölmerich
Sep 30, 1998·Gastroenterology·F M RuemmeleE G Seidman
Nov 30, 2000·The American Journal of Gastroenterology·M FarmerS Galandiuk
Mar 23, 2002·Gastroenterology·Tariq AhmadDerek P Jewell
Mar 23, 2002·Gastroenterology·Andrew P CuthbertChristopher G Mathew
Jul 10, 2002·Gastroenterology·Severine VermeireUNKNOWN Belgian Group of Infliximab Expanded Access Program and Fondation Jean Dausset CEPH, Paris, France
Jan 1, 2003·Human Immunology·Jesús K Yamamoto-FurushoJulio Granados
Jun 24, 2003·The American Journal of Gastroenterology·Sunanda V KaneStephen B Hanauer
Feb 7, 2004·Human Molecular Genetics·Christopher G Mathew, Cathryn M Lewis
Mar 30, 2004·The American Journal of Gastroenterology·Bill NewmanKatherine Siminovitch
Aug 18, 2004·Digestive Diseases and Sciences·Stephan BuderusMichael J Lentze
Nov 24, 2004·The American Journal of Gastroenterology·Ian Craig LawranceRupert Leong
Oct 14, 2005·Human Molecular Genetics·Keiko YamazakiYusuke Nakamura

❮ Previous
Next ❯

Citations

Oct 28, 2019·European Journal of Gastroenterology & Hepatology·Sarai Quiroz-CruzSalvador Fonseca-Coronado
Mar 10, 2020·Expert Opinion on Emerging Drugs·Nicola PuglieseSilvio Danese
Sep 12, 2020·Nature Reviews. Disease Primers·Taku KobayashiToshifumi Hibi
Oct 1, 2019·Gastroenterology Research and Practice·Marco DapernoPaolo Gionchetti
Apr 8, 2020·World Journal of Gastroenterology : WJG·Zhen ZengHu Zhang
Nov 19, 2019·Reviews on Recent Clinical Trials·Basant K Puri
Nov 19, 2019·Frontiers in Genetics·Zhen ZengHu Zhang
Oct 10, 2020·Nature Reviews. Disease Primers·Emanual MaverakisSinéad M Langan
May 14, 2021·Clinical Epigenetics·M HornschuhJ Däbritz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.