Molecular diagnosis and clinical relevance of t(9;22), t(4;11) and t(1 ;19) chromosome abnormalities in a consecutive group of 141 adult patients with acute lymphoblastic leukemia

Leukemia & Lymphoma
A RambaldiT Barbui

Abstract

Over a time period of five years leukemic blast samples from 141 consecutive patients with adult ALL were referred to our laboratory, for molecular evaluation of chromosome abnormalities. The t(9;22), t(4;11) and t(1;19) which are most commonly found in adult ALL with a B-precursor phenotype were molecularly analyzed by similar RT-PCR based protocols. BCR-ABL transcripts generated by the t(9;22) translocation were demonstrated in 36 patients (25%) and were restricted to the 109 patients with B precursor ALL (33% of this group). Of 83 patients showing a, common phenotype (CD10+), 34 were BCR-ABL positive (41%) whereas only 2 out of 26 with Null ALL (HLADr+, CD19+, CD10) were positive. Interestingly, the percent of BCR-ABL positive CD1O+ ALL increases significantly with age being 20% in patients less than 30 years old and more than 50% in older patients. None of the T-ALL (24 patients) and B-ALL (8 patients) were positive. The majority of cases (67%) showed the p190 gene subtype. The cytogenetic diagnosis of Philadelphia chromosome was always confirmed by the molecular analysis and this approach allowed for the detection of the presence of the BCR-ABL rearrangement in 26 patients when a negative result or no metaphases were obtai...Continue Reading

References

Nov 1, 1990·The American Journal of Medicine·R WaltersE J Freireich
Jun 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J GaynorT Gee
Dec 1, 1993·British Journal of Haematology·A Z Rohatiner, T A Lister
Oct 28, 1993·The New England Journal of Medicine·G K RiveraW M Crist

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Citations

May 4, 2002·Best Practice & Research. Clinical Haematology·Letizia Foroni, A Victor Hoffbrand
Jul 3, 2002·Leukemia·O Hrusák, A Porwit-MacDonald
Oct 28, 2011·Cytometry. Part B, Clinical Cytometry·Fiona E CraigSteven H Swerdlow

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