Molecular diagnosis of culture-negative cerebral nocardiosis due to Nocardia abscessus

Diagnostic Microbiology and Infectious Disease
Hélène MarchandinF Laurent

Abstract

We describe a case of culture-negative cerebral nocardiosis in a 34-year-old immunocompetent man who presented multiple cerebral abscesses. All bacteriologic cultures were negative. Nocardiosis was diagnosed by using a direct genus-specific 16S rDNA amplification method, and Nocardia abscessus was identified by hsp65 sequence analysis. The patient is alive and well on imipenem and doxycycline therapy, 14 months after onset.

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Apr 5, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·W L LiuP R Hsueh
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