Molecular diagnosis of toxoplasmosis: recent advances and a look to the future.

Expert Review of Anti-infective Therapy
Marie Gladys RobertHervé Pelloux

Abstract

Toxoplasmosis is a globally distributed parasitic infection that can be particularly severe when opportunistic or congenital. Its diagnosis requires accurate and rapid techniques that rely mainly on serology and molecular methods. The aim of this review was to discuss the positioning of the molecular diagnosis of toxoplasmosis according to the different clinical situations possibly resulting from infection with T. gondii, and to detail recent developments in this technique. The English and French literature were searched with the following keywords: 'Toxoplasmosis', "Molecular diagnosis" and 'PCR'. Molecular techniques have revolutionized the diagnosis of toxoplasmosis, and practices have considerably evolved over the past decades. However, there is still a high degree of inter-laboratory heterogeneity which impairs comparisons between results and studies. Efforts to standardize practices are underway.

References

Nov 1, 1992·Journal of Clinical Microbiology·S F ParmleyJ S Remington
Aug 15, 1992·American Journal of Ophthalmology·P D GlasnerR Belfort Júnior
Dec 1, 1991·Journal of Clinical Pathology·J CazenaveJ Begueret
Sep 15, 1994·The New England Journal of Medicine·P HohlfeldM Vidaud
Dec 1, 1993·The Journal of Infectious Diseases·S BretagneJ Fleury-Feith
Jul 1, 1993·Journal of Clinical Microbiology·J Dupouy-CametF Derouin
May 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E Schoondermark-van de VenW Melchers
Oct 1, 1996·Journal of Clinical Microbiology·I FuentesJ Alvar
Oct 1, 1996·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M LebechE Petersen
Nov 4, 2000·Journal of Clinical Microbiology·M H LinC P Tseng
Nov 14, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R MartinoC Cordonnier
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S BretagneC Cordonnier
Jun 18, 2002·Scandinavian Journal of Infectious Diseases·Philippe BossiFrançois Bricaire
Aug 1, 2002·Archives of Ophthalmology·Gary N HollandG Richard O'Connor
Nov 1, 2002·Journal of Clinical Microbiology·B CarmeM L Dardé
Dec 4, 2003·American Journal of Ophthalmology·Gary N Holland
Jun 15, 2004·Lancet·J G Montoya, O Liesenfeld
Sep 18, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S JalalUNKNOWN ESCMID Study Group on Toxoplasmosis
Oct 9, 2004·Journal of Clinical Microbiology·José E VidalVera Lucia Pereira-Chioccola
Dec 23, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rodrigo MartinoUNKNOWN Infectious Disease Working Party of the European Group for Blood and Marrow Transplantation
Dec 15, 2005·The Journal of Infection·Francine De Salvador-GuillouëtPierre Marty
Feb 7, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bálint NagyZoltán Papp
Mar 7, 2006·Journal of Clinical Microbiology·S CassaingJ F Magnaval
Jul 25, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Karine KaiserFrançois Peyron
Jan 16, 2007·Lancet·UNKNOWN SYROCOT (Systematic Review on Congenital Toxoplasmosis) study groupRuth Gilbert
Feb 17, 2007·Pathologie-biologie·D MaubonH Pelloux
Feb 17, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Fabio Eudes LealEsper Georges Kallas
Aug 28, 2007·The Pediatric Infectious Disease Journal·Hélène Fricker-HidalgoHervé Pelloux
Apr 11, 2008·Journal of Clinical Microbiology·Patrick BastienUdo Reischl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Das Medizinische Laboratorium
H Aspöck
Nederlands tijdschrift voor geneeskunde
H de Roever-Bonnet, H C Hillenbrink
Deutsche medizinische Wochenschrift
G Piekarski
British Medical Journal
G N Dutton
Tropical and Geographical Medicine
H de Roever-Bonnet, H C Hillenbrink
© 2021 Meta ULC. All rights reserved