Molecular diagnostic applications of DNA methylation technology

Clinical Biochemistry
Susan E Cottrell

Abstract

Cancer arises due to the accumulation of DNA modifications that give cells a selective growth advantage. One common DNA modification is promoter hypermethylation associated with loss of expression of a tumor suppressor gene. The methylation status of a specific sequence or the pattern of methylation across the genome can be readily measured, and these sequences and analytical methods are being rapidly developed for molecular diagnostic applications. Detection of certain methylation events can be used for early detection of tumors, and analysis of patterns of methylation across the genome might provide information on disease subtype, aggressiveness, and treatment response. DNA methylation-based molecular diagnostic assays are particularly attractive because of the stability of the target analyte (DNA) and the potential sensitivity of the assays. As the field matures, methylation-based assays will make a major contribution to the field of molecular diagnostics, providing tools to fill unmet needs in current diagnostic and treatment plans for many types of cancer.

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M FrommerC L Paul
Apr 1, 1993·Electrophoresis·Y HayashizakiS Wada
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·J P IssaS B Baylin
Jun 15, 1997·Nucleic Acids Research·Z Xiong, P W Laird
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Feb 9, 1999·Human Molecular Genetics·T H HuangD E Laux
Mar 2, 1999·Journal of the National Cancer Institute·S A AhrendtD Sidransky
Mar 29, 2000·Nucleic Acids Research·C A EadsP W Laird
Nov 9, 2000·The New England Journal of Medicine·M EstellerJ G Herman
Nov 18, 2000·Journal of the National Cancer Institute·K KawakamiS J Meltzer
Mar 7, 2001·The New England Journal of Medicine·U Schlegel
Jun 30, 2001·The New England Journal of Medicine·O I Olopade, T Grushko
Jul 19, 2001·Journal of the National Cancer Institute·M S PepeY Yasui
Feb 28, 2002·Nucleic Acids Research·Péter AdorjánAlexander Olek
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Daiya Takai, Peter A Jones
Mar 28, 2002·Nucleic Acids Research·Jordi FrigolaMiguel A Peinado
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jingfeng LiEugene R Zabarovsky
Nov 5, 2002·Analytical Biochemistry·Robert P BalogHarold R Garner
Dec 4, 2002·Journal of Cellular Biochemistry·Huidong ShiTim Hui-Ming Huang
Mar 15, 2003·Science·Hengmi CuiAndrew P Feinberg
Apr 3, 2003·Nature Reviews. Cancer·Peter W Laird
Apr 15, 2003·Nature Medicine·Toshiyasu TaniguchiAlan D D'Andrea
Apr 25, 2003·Nucleic Acids Research·Jörg TostIvo Glynne Gut
Apr 25, 2003·International Journal of Cancer. Journal International Du Cancer·Hiroshi NakayamaAkimasa Nakao
May 2, 2003·Annals of the New York Academy of Sciences·Susan E Cottrell, Peter W Laird
Jun 10, 2003·International Journal of Cancer. Journal International Du Cancer·Karen UhlmannPeter W Laird

❮ Previous
Next ❯

Citations

Nov 30, 2006·Journal of Applied Genetics·Jaroslaw Paluszczak, Wanda Baer-Dubowska
Jun 29, 2010·Surgery Today·Makoto Suzuki, Ichiro Yoshino
May 19, 2005·Journal of Personality and Social Psychology·Catherine A Cottrell, Steven L Neuberg
Apr 6, 2006·Journal of Personality and Social Psychology·Norman P Li, Douglas T Kenrick
Dec 18, 2007·Nucleic Acids Research·Jairo RodriguezMiguel A Peinado
Feb 1, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David Rodenhiser, Mellissa Mann
Dec 1, 2009·Epigenomics·Tomasz K Wojdacz
Jan 14, 2009·Yi chuan = Hereditas·Jian-Xin Tan, Yu-Jie Sun
May 11, 2012·Chinese Journal of Cancer·Ji-Sheng LiLi-Li Li
Oct 7, 2008·Journal of Cancer Research and Clinical Oncology·Kiruthika BalasubramanianShylaja Mallaiah Dharmesh
Sep 1, 2007·Expert Opinion on Medical Diagnostics·Ashley G Rivenbark, William B Coleman
Apr 18, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Fleur S PetersKarin Boer
Jun 26, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J ChenX Guan
Jun 16, 2006·BioTechniques·Jörg TostIvo Glynne Gut
Dec 21, 2006·The Journal of Pathology·P Jelinic, P Shaw
Jun 15, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Farid E Ahmed
May 8, 2018·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Shijie MoCaiyong Lai
Oct 23, 2010·BioTechniques·Keith N Rand, Peter L Molloy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.