Molecular diagnostic testing for infectious diseases using TMA technology

Expert Review of Molecular Diagnostics
C S Hill

Abstract

Molecular diagnostic tests based on nucleic acid amplification technologies (NAATs) have become widely established in clinical microbiology laboratories in recent years. The acceptance of these tests has been driven by the development of more accurate and less labor-intensive commercial assay kits by diagnostic manufacturers. Infectious disease diagnostic assays using transcription-mediated amplification (TMA) NAAT have become increasingly popular in many clinical microbiology laboratories. Recent technology developments have improved the performance and simplified the use of the TMA assays. These new technologies have been applied to the development of multiplex TMA tests to improve the testing accuracy for organisms, such as Chlamydia trachomatis and Neisseria gonorrhoeae in clinical microbiology laboratories. TMA tests for HIV-1 and HCV have also led to improvements in blood bank testing which can improve the safety of the public blood supply.

Citations

May 21, 2013·Molecular Diagnosis & Therapy·Anthony P Malanoski, Baochuan Lin
Aug 11, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Janel DockterCristina Giachetti
Jul 10, 2004·Journal of Clinical Microbiology·Charlotte A GaydosThomas C Quinn
Mar 8, 2013·Annual Review of Food Science and Technology·Kristin LivezeyMichael M Becker
Dec 23, 2015·Expert Review of Molecular Diagnostics·Stacy G BealKenneth H Rand
Oct 18, 2011·Diagnostic Microbiology and Infectious Disease·Victoria DoseevaIrina Nazarenko
Nov 29, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Juliane Haedicke, Thomas Iftner
Sep 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Elizabeth A Mothershed, Anne M Whitney
Jul 26, 2015·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Mark HopkinsAnna Maria Geretti
Oct 12, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·K SaunéJ Izopet
Nov 15, 2008·BioTechniques·Yanhong TongHuimin Kong
Jun 28, 2008·Lab on a Chip·Shantanu BhattacharyaRashid Bashir
Feb 3, 2007·Expert Review of Anti-infective Therapy·Guy Vernet
Jun 23, 2012·The Analyst·Amit SinghStephane Evoy
Dec 22, 2010·Expert Review of Molecular Diagnostics·Reem R Al Olaby, Hassan M E Azzazy
Jul 11, 2006·Expert Review of Molecular Diagnostics·Max A Chernesky, Dan E Jang
Mar 10, 2017·Expert Review of Molecular Diagnostics·Harald H Kessler, Evelyn Stelzl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.