Molecular diagnostics in monogenic and multifactorial forms of type 2 diabetes

Expert Review of Molecular Diagnostics
M I McCarthy, A T Hattersley

Abstract

Type 2 diabetes represents a major and increasing contributor to morbidity and mortality worldwide. Of the world's population, 10% either have Type 2 diabetes, or will develop it during their lifetime. Realization that inherited factors play a leading role in determining individual susceptibility to this condition provides a framework for improved molecular understanding of disease pathogenesis through susceptibility gene discovery. In particular, identification and characterization of these susceptibility variants should lead to improved targeting of available preventative and therapeutic measures and increasingly 'personalized' therapy. This article surveys present knowledge about the genetic basis of Type 2 diabetes and discusses the current and future role of genetic diagnostics, with an emphasis on lessons learned from study of monogenic forms of the disease.

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Citations

Sep 22, 2012·Current Diabetes Reports·Tomasz KlupaMaciej T Malecki
Jun 1, 2005·Archives of Medical Research·María Teresa Tusié Luna
Oct 29, 2003·Diabetes Research and Clinical Practice·Maciej T MaleckiJacek Sieradzki
Jan 28, 2003·Drug Discovery Today·Jeffrey S Ross, Geoffrey S Ginsburg
Sep 24, 2009·Nutrition Research Reviews·Wendy J van der Spuy, Etheresia Pretorius
May 10, 2007·Diabetes, Obesity & Metabolism·Maciej T Malecki, Wojciech Mlynarski
Aug 21, 2010·Health Policy·Serban Dinca-PanaitescuDennis Raphael
Nov 18, 2008·Diabetes Research and Clinical Practice·Maciej T MaleckiJan Skupien
Aug 5, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P Palsamy, S Subramanian
Jun 15, 2007·Archives of Medical Research·Reza MeshkaniKhosrow Adeli
Nov 9, 2010·European Journal of Clinical Investigation·Oscar Rubio-CabezasUNKNOWN CEED3 Consortium
Dec 8, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Manige Konig, Alan R Shuldiner
Jan 30, 2004·Diabetes·J Antonie MaassenHerman H P J Lemkes
Mar 3, 2018·Journal of Diabetes Investigation·Fangying XieRonald Cw Ma
Jul 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Mark I McCarthy, Philippe Froguel
Jan 11, 2003·American Journal of Clinical Pathology·Jeffrey S Ross, Geoffrey S Ginsburg
Jun 29, 2021·Journal of Diabetes and Metabolic Disorders·Olusola Olalekan ElekofehintiOluwamodupe Cecilia Ejelonu

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