Molecular Diagnostics in Pathology: Time for a Next-Generation Pathologist?

Archives of Pathology & Laboratory Medicine
Matteo Fassan

Abstract

- Comprehensive molecular investigations of mainstream carcinogenic processes have led to the use of effective molecular targeted agents in most cases of solid tumors in clinical settings. - To update readers regarding the evolving role of the pathologist in the therapeutic decision-making process and the introduction of next-generation technologies into pathology practice. - Current literature on the topic, primarily sourced from the PubMed (National Center for Biotechnology Information, Bethesda, Maryland) database, were reviewed. - Adequate evaluation of cytologic-based and tissue-based predictive diagnostic biomarkers largely depends on both proper pathologic characterization and customized processing of biospecimens. Moreover, increased requests for molecular testing have paralleled the recent, sharp decrease in tumor material to be analyzed-material that currently comprises cytology specimens or, at minimum, small biopsies in most cases of metastatic/advanced disease. Traditional diagnostic pathology has been completely revolutionized by the introduction of next-generation technologies, which provide multigene, targeted mutational profiling, even in the most complex of clinical cases. Combining traditional and molecular k...Continue Reading

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Citations

Jul 25, 2018·Archives of Pathology & Laboratory Medicine·Joseph H Keffer
May 18, 2019·Archives of Pathology & Laboratory Medicine·Kenneth P H Pritzker, Heikki J Nieminen
Aug 14, 2019·Cancer Cell International·Francesca GaluppiniRaffaele Baffa
Nov 15, 2019·Virchows Archiv : an International Journal of Pathology·Matteo FassanFotios Loupakis
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May 13, 2021·Best Practice & Research. Clinical Gastroenterology·Gianluca BusinelloMatteo Fassan
Apr 25, 2019·Acta Cytologica·Gordon H YuKaren S Gustafson

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