PMID: 8946695Sep 1, 1996Paper

Molecular diversity among the trypsin resistant surface proteins of group B streptococci

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
A E Flores, P Ferrieri

Abstract

The alpha (alpha) component of the c protein and R proteins are trypsin resistant, but antigenically distinct, proteins on the cell surface of some but not all strains of group B streptococci (GBS). These two classes of proteins, along with the group and type polysaccharide, can be used to characterize strains of GBS. Four species of R protein (R1 through R4) have been described. We studied trypsin extracts from numerous strains of GBS by immunodiffusion in agarose and polyacrylamide gel electrophoresis/Western blot. Sera monospecific for alpha, R1 and R4 were used to immunoprecipitate/blot the proteins. The molecular weight of the blotted proteins was determined. Although by immunodiffusion the proteins within a class were identical to each other, great heterogeneity in size and blotting pattern was found within each class. Variation was independent of the polysaccharide serotype. Multiple molecular weight species were seen for alpha, R1 and R4 proteins. For a given strain, the various forms of alpha or R1 appeared to form a multiple size ladder; those of R4 were fewer and closer in size. The highest form of alpha ranged from 85 to 170 kDa, with 45 kDa being the highest form for some rare GBS strains. For R4 the predominant an...Continue Reading

References

Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L MichelF M Ausubel
Jan 1, 1992·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L BevangerA I Naess
Aug 1, 1991·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·I W Wibawan, C Lämmler
May 1, 1990·Reviews of Infectious Diseases·P Ferrieri
Jul 1, 1988·Reviews of Infectious Diseases·P Ferrieri
Feb 1, 1995·Current Opinion in Pediatrics·K M Boyer
Jan 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A E FloresP Ferrieri

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Citations

Feb 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D F ZaleznikC J Baker
Oct 16, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A I KvamJ A Maeland
May 1, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·S R MoyoL Bevanger
Nov 13, 2004·Clinical and Diagnostic Laboratory Immunology·Johan A MaelandRandi Valsoe Lyng
Nov 9, 2005·Clinical and Diagnostic Laboratory Immunology·Johan A MaelandRandi Valsoe Lyng
Jul 9, 2010·Journal of Clinical Microbiology·Michelle J DiedrickPatricia Ferrieri
Jan 2, 2009·Microbiology·Christofer KarlssonInga-Maria Frick
Dec 30, 2016·Journal of Medical Microbiology·Christina GabrielsenJan Egil Afset
Dec 30, 2014·Clinical and Vaccine Immunology : CVI·Johan A MaelandAndreas Radtke
Jul 16, 1999·Journal of Clinical Microbiology·G ArakereC E Frasch

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