Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Luciana MéndezErnesto G Mata

Abstract

The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary library, diversity was expanded by applying different cleavage conditions, leading to a series of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through incorporation of a chalcone moiety.

References

Jan 1, 1999·Bioorganic & Medicinal Chemistry Letters·A D BorthwickT S Mansour
Jul 6, 2000·Bioorganic & Medicinal Chemistry·G VeinbergE Lukevics
Sep 18, 2001·The Journal of Organic Chemistry·E AlonsoJ González
Dec 7, 2002·The Journal of Organic Chemistry·William P MalachowskiRobert L Broadrup
Dec 7, 2002·Bioorganic & Medicinal Chemistry Letters·Nian E ZhouRajeshwar Singh
Dec 28, 2002·Journal of Medicinal Chemistry·Indrani BanikBimal K Banik
Mar 29, 2003·The Journal of Organic Chemistry·Rita AnnunziataAlessandra Puglisi
May 13, 2003·Journal of Combinatorial Chemistry·Carina M L DelpiccoloErnesto G Mata
Dec 25, 2003·Angewandte Chemie·Martin D Burke, Stuart L Schreiber
Jul 29, 2004·Current Medicinal Chemistry·Duane A Burnett
Mar 15, 2005·Journal of Combinatorial Chemistry·Carina M L DelpiccoloErnesto G Mata
May 24, 2005·Biochemical and Biophysical Research Communications·Hong-Fang JiHong-Yu Zhang
Aug 9, 2005·Bioorganic & Medicinal Chemistry·Gianfranco CainelliArianna Quintavalla
Sep 21, 2005·Organic & Biomolecular Chemistry·Tobias RitterErick M Carreira
Oct 14, 2005·Journal of the American Chemical Society·Arnab K ChatterjeeRobert H Grubbs
May 4, 2006·Journal of the American Chemical Society·Lei JiaoJiaxi Xu
Aug 26, 2006·The Journal of Organic Chemistry·Yikai WangJiaxi Xu
Feb 27, 2007·Journal of Combinatorial Chemistry·Luciana MéndezErnesto G Mata
Jul 14, 2007·Current Medicinal Chemistry·Cláudio Viegas-JuniorCarlos Alberto Manssour Fraga
Nov 16, 2007·Organic Letters·Amanda L Garner, Kazunori Koide
Feb 9, 2008·The Journal of Organic Chemistry·Andrés A Poeylaut-PalenaErnesto G Mata
Sep 25, 2010·Nature Communications·Warren R J D GallowayDavid R Spring
Nov 4, 2010·Bioorganic & Medicinal Chemistry·Eric M GuantaiKelly Chibale
May 13, 2011·Chemical Society Reviews·Cornelius J O'ConnorDavid R Spring
Jun 28, 2011·Bioorganic & Medicinal Chemistry Letters·Pardeep SinghKelly Chibale
Apr 12, 2012·Chemical Society Reviews·Cornelius J O' ConnorDavid R Spring
Apr 24, 2012·Journal of Medicinal Chemistry·Matthias D'hoogheNorbert De Kimpe
May 21, 2013·Bioorganic & Medicinal Chemistry·Stéphanie Vandekerckhove, Matthias D'hooghe
Sep 17, 2013·Chemical Biology & Drug Design·Raghu RajVipan Kumar
Feb 18, 2014·European Journal of Medicinal Chemistry·Nikhilesh AryaKishor S Jain
Apr 15, 2015·Accounts of Chemical Research·Peter H Seeberger
Apr 16, 2016·Future Cardiology·Peter P TothAndrew M Tershakovec

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR
column chromatography

Software Mentioned

HyperChem
AM1

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.