PMID: 8618961Apr 1, 1996

Molecular diversity of myofibrillar proteins: gene regulation and functional significance

Physiological Reviews
S Schiaffino, C Reggiani


Myofibrillar proteins exist as multiple isoforms that derive from multigene (isogene) families. Additional isoforms, including products of tropomyosin, myosin light chain 1 fast, troponin T, titin, and nebulin genes, can be generated from the same gene through alternative splicing or use of alternative promoters. Myofibrillar protein isogenes are differentially expressed in various muscle types and fiber types but can be coexpressed within the same fiber. Isogenes are regulated by transcriptional and posttranscriptional mechanisms; however, specific regulatory sequences and transcriptional factors have not yet been identified. The pattern of isogene expression varies during muscle development in relation to the different origin of myogenic cells and primary/secondary fiber generations and is affected by neural and hormonal influences. The variable expression of myofibrillar protein isoforms is a major determinant of the contractile properties of skeletal muscle fibers. The diversity among isomyosins is related to the differences in the parameters of chemomechanical transduction as ATP hydrolysis rate and shortening velocity. Troponin and tropomyosin isoforms determine the variable sensitivity to calcium, whereas titin isoforms ...Continue Reading


May 1, 1997·Circulation Research·S Schiaffino
Mar 31, 1998·Developmental Dynamics : an Official Publication of the American Association of Anatomists·G McKoyG Goldspink
Jun 1, 1997·The American Journal of Physiology·J L Andersen, S Schiaffino
Feb 10, 1999·The American Journal of Physiology·D S O'NeillJ A Houmard
Mar 6, 1999·Journal of Applied Physiology·L V Thompson, M Brown
Jun 16, 1999·Journal of Applied Physiology·J A HoumardG L Dohm
Feb 5, 2000·Equine Veterinary Journal. Supplement·José-Luis L Rivero, A L Serrano
Apr 1, 2000·The Journal of Biological Chemistry·I AgarkovaJ C Perriard
Apr 25, 2000·The Journal of Biological Chemistry·X BigardR Ventura-Clapier
Sep 22, 2000·Microscopy Research and Technique·E Bandman, B W Rosser
Jul 7, 2000·Muscle & Nerve·J L Andersen, P Aagaard
Jun 9, 2000·Annual Review of Physiology·J Robbins
Sep 22, 2000·Microscopy Research and Technique·D L AllenL A Leinwand
Jan 11, 2001·Muscle & Nerve·A MegighianD Danieli-Betto
Nov 22, 2000·Drugs & Aging·L Larsson, B Ramamurthy
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P J ReiserC Schomisch Moravec
May 15, 2001·Acta Physiologica Scandinavica·B O EijndeP Hespel
May 15, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·T M van Eijden, S J Turkawski
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A FrigeriM Svelto
Jan 16, 2002·The Journal of Biological Chemistry·William IrwinPaolo Bernardi
Nov 24, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·M V Westfall, J M Metzger
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sophie TalonClaude Léoty
Oct 22, 2002·American Journal of Physiology. Cell Physiology·Richard W TsikaGretchen L Tsika
Nov 27, 2002·Muscle & Nerve·Derron L Bishop, Richard L Milton
Aug 5, 2003·Pflügers Archiv : European journal of physiology·Oleg AndruchovStefan Galler
Aug 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Karin EizemaWim A Weijs
Jul 28, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Liancai MuIra Sanders
Sep 25, 2004·Muscle & Nerve·Robert J CallisterDouglas G Stuart

Related Concepts

Calcium [EPC]
Transcription, Genetic
Troponin T Assay
TTN gene

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.