Molecular Drivers of Breast Implant-Associated Anaplastic Large Cell Lymphoma

Plastic and Reconstructive Surgery
Piers BlomberyH Miles Prince

Abstract

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell lymphoproliferative disorder occurring in patients with breast implants. Genomic characterization performed in BIA-ALCL to date has demonstrated qualitatively similar molecular abnormalities to those seen in its more common counterpart [ALK-negative systemic anaplastic large cell lymphoma (sALCL)] including JAK/STAT activation and MYC/TP53 dysregulation. Despite these observed similarities at the molecular level, the outcomes of sALCL and BIA-ALCL are markedly different with sALCL typically associated with an aggressive course and inferior outcomes compared with BIA-ALCL. This review describes the findings of high-throughput sequencing and other genomic characterization to date in BIA-ALCL and the insights these studies have given into the molecular drivers of this rare lymphoma subtype.

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Citations

Dec 10, 2019·CA: a Cancer Journal for Clinicians·Enrica Marchi, Owen A O'Connor
Oct 15, 2019·Plastic and Reconstructive Surgery·Ryan C DeCosterHenry C Vasconez
Jan 3, 2020·Aesthetic Surgery Journal·Trina GhoshTerence M Myckatyn
Jul 23, 2020·Annals of Surgery·Jonas A NelsonColleen M McCarthy
Dec 18, 2019·Aesthetic Plastic Surgery·Guillermo Ramos-GallardoEnrique Javier Cedillo-Alemán
Jun 27, 2020·Plastic and Reconstructive Surgery·Erica LeeJustin M Sacks
Oct 7, 2020·Aesthetic Surgery Journal·Fabio Santanelli di PompeoUNKNOWN European Association of Plastic Surgeons (EURAPS) Committee on Device Safety and Development
Dec 29, 2020·Plastic and Reconstructive Surgery·Ryan C DeCosterHenry C Vasconez
Nov 8, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Milena Rondón-LagosMaribel Forero-Castro

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