Molecular endoscopic imaging in cancer

Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society
Shakil AhmedHelmut Neumann

Abstract

Cancer is one of the major causes of death in both the USA and Europe. Molecular imaging is a novel field that is revolutionizing cancer management. It is based on the molecular signature of cells in order to study the human body both in normal and diseased conditions. The emergence of molecular imaging has been driven by the difficulties associated with cancer detection, particularly early-stage premalignant lesions which are often unnoticed as a result of minimal or no structural changes. Endoscopic surveillance is the standard method for early-stage cancer detection. In addition to recent major advancements in endoscopic instruments, significant progress has been achieved in the exploration of highly specific molecular probes and the combination of both will permit significant improvement of patient care. In this review, we provide an outline of the current status of endoscopic imaging and focus on recent applications of molecular imaging in gastrointestinal, hepatic and other cancers in the context of detection, targeted therapy and personalized medicine. As new imaging agents have the potential to broadly expand our cancer diagnostic capability, we will also present an overview of the main types of optical molecular probes...Continue Reading

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Citations

Sep 12, 2020·Molecular Oncology·Yubo TangRebecca Richards-Kortum
Sep 14, 2019·Therapeutic Advances in Gastrointestinal Endoscopy·Shakil AhmedHelmut Neumann
Mar 17, 2020·Cellular and Molecular Bioengineering·Mahboubeh S NooriDouglas J Goetz

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