Molecular engineering of antimicrobial peptide (AMP)-polymer conjugates.

Biomaterials Science
Zixian CuiRachel A Letteri

Abstract

As antimicrobial resistance becomes an increasing threat, bringing significant economic and health burdens, innovative antimicrobial treatments are urgently needed. While antimicrobial peptides (AMPs) are promising therapeutics, exhibiting high activity against resistant bacterial strains, limited stability and toxicity to mammalian cells has hindered clinical development. Attaching AMPs to polymers provides opportunities to present AMPs in a way that maximizes bacterial killing while enhancing compatibility with mammalian cells, stability, and solubility. Conjugation of an AMP to a linear hydrophilic polymer yields the desired improvements in stability, mammalian cell compatibility, and solubility, yet often markedly reduces bactericidal effects. Non-linear polymer architectures and supramolecular assemblies that accommodate multiple AMPs per polymer chain afford AMP-polymer conjugates that strike a superior balance of antimicrobial activity, mammalian cell compatibility, stability, and solubility. Therefore, we review the design criteria, building blocks, and synthetic strategies for engineering AMP-polymer conjugates, emphasizing the connection between molecular architecture and antimicrobial performance to inspire and enabl...Continue Reading

References

Oct 1, 1994·Biomaterials·B A Zielinski, P Aebischer
Jul 27, 2001·Nature·S Fernandez-LopezM R Ghadiri
Feb 22, 2003·Il Farmaco·Andrea GuiottoFrancesco M Veronese
Jul 13, 2004·Biomacromolecules·Anthony J ConvertineCharles L McCormick
Jan 29, 2005·Drug Discovery Today·Elizabeth R Gillies, Jean M J Fréchet
Feb 11, 2005·Nature Reviews. Microbiology·Kim A Brogden
Aug 16, 2005·Angewandte Chemie·Stefan BräseViktor Zimmermann
Jun 9, 2006·Journal of Medicinal Chemistry·Zhigang LiuNeville R Kallenbach
Feb 27, 2007·Biochimica Et Biophysica Acta·Yuichi ImuraKatsumi Matsuzaki
Jul 31, 2007·Biochimica Et Biophysica Acta·Yuichi ImuraKatsumi Matsuzaki
Oct 10, 2007·Chembiochem : a European Journal of Chemical Biology·Zhigang LiuNeville R Kallenbach
Mar 5, 2008·Biopolymers·Abhigyan SomGregory N Tew
Jun 7, 2008·Chemical Communications : Chem Comm·Marc A Gauthier, Harm-Anton Klok
Jul 5, 2008·Nature Protocols·Guillermo RepettoJorge L Zurita
Sep 18, 2008·Molecular Aspects of Medicine·Henry Jay FormanAlessandra Rinna
Oct 11, 2008·Journal of Biochemistry·Genghui ZhangHusheng Yan
Jan 28, 2009·Chemistry & Biology·Kai HilpertRobert E W Hancock
Apr 10, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Pranav R JoshiJennifer A Neff
Feb 18, 2010·Chemical Communications : Chem Comm·Maisie J JoralemonTodd Emrick
Mar 24, 2010·Chemical Society Reviews·Charles E HoyleChristopher N Bowman
May 11, 2010·Cold Spring Harbor Perspectives in Biology·Thomas J SilhavySuzanne Walker
Sep 14, 2010·International Journal of Peptide Research and Therapeutics·S P LiuR W Beuerman
Sep 30, 2010·Chemical Society Reviews·Meredith A Mintzer, Mark W Grinstaff
Nov 26, 2010·Chemical Society Reviews·Chun FengXiaoyu Huang
Dec 21, 2010·Biomaterials·Nikken WiradharmaYi-Yan Yang
Apr 25, 2012·Biochimica Et Biophysica Acta·Cristina ChamorroRoland J Pieters
May 9, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Andreas Bernkop-Schnürch, Sarah Dünnhaupt
Jan 22, 2013·Annual Review of Physical Chemistry·Jessica Y ShuTing Xu
Nov 2, 2013·Trends in Biotechnology·Mario SalwiczekHelmut Thissen
May 9, 2014·Journal of the American Chemical Society·Maarten DanialSébastien Perrier
Oct 12, 2014·Applied and Environmental Microbiology·Morten HyldgaardRikke L Meyer
Nov 2, 2014·Journal of the American Chemical Society·Nicolas J TreatCraig J Hawker
Feb 11, 2015·Biomacromolecules·Prashant KumarSuzana K Straus

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Methods Mentioned

BETA
amidation
NMR
dynamic light scattering
atomic force microscopy

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