Molecular engineering of nonmetallic biosensors for CEST MRI

ACS Chemical Biology
Amnon Bar-ShirAssaf A Gilad

Abstract

Recent advancements in molecular and synthetic biology, combined with synthetic chemistry and biotechnology, have opened up new opportunities to engineer novel platforms that can monitor complex biological processes with various noninvasive imaging modalities. After decades of using gadolinium- or iron-based metallic sensors for MRI, the recently developed chemical exchange saturation transfer (CEST) contrast mechanism has created an opportunity for rational design, in silico, of nonmetallic biosensors for MRI. These biomolecules are either naturally occurring compounds (amino acids, sugars, nucleosides, native proteins) or can be artificially engineered (synthetic probes or recombinant proteins). They can be administered either as exogenous agents or can be genetically (over)expressed. Moreover, they can be precisely engineered to achieve the desired biochemical properties for fine tuning optimized imaging schemes. The availability of these agents marks the dawn of a new scientific era for molecular and cellular MRI.

References

Mar 1, 1988·The Journal of Cell Biology·R G Anderson, L Orci
Feb 1, 1984·Quarterly Reviews of Biophysics·J R Alger, R G Shulman
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G A SmithP G Morris
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·E M ThompsonJ P Renard
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·L D StegmanB D Ross
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·S S GambhirH R Herschman
Nov 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K M Ward, R S Balaban
Aug 30, 2001·Journal of the American Chemical Society·N GoffeneyP C van Zijl
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·J ZhangR Y Tsien
Mar 26, 2003·Nature Biotechnology·Guenther KoehneJuri G Gelovani Tjuvajev
May 28, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karim SnoussiPeter C M van Zijl
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Thomas A PologrutoKarel Svoboda
Nov 2, 2004·Nature Reviews. Cancer·Robert A Gatenby, Robert J Gillies
Nov 5, 2004·NMR in Biomedicine·Jeff W M Bulte, Dara L Kraitchman
Mar 22, 2005·Nature Medicine·Guillem GenoveEric T Ahrens
Mar 31, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Donald E WoessnerA Dean Sherry
Apr 2, 2005·Neoplasia : an International Journal for Oncology Research·Batya CohenMichal Neeman
Aug 6, 2005·Nature Biotechnology·Jeff W M Bulte
Jan 28, 2006·Assay and Drug Development Technologies·Grace K Y ChanPeter B Simpson
Sep 12, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Seth A SmithPeter C M van Zijl
Sep 20, 2006·Cancer Research·Jung-whan Kim, Chi V Dang
Sep 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tatjana AtanasijevicAlan Jasanoff
Oct 21, 2006·Science·Leif SchröderAlexander Pines
Jan 30, 2007·Nature Biotechnology·Assaf A GiladPeter C M van Zijl
Mar 14, 2007·Nature Medicine·Batya CohenMichal Neeman
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Peter C M van ZijlA Dean Sherry
Oct 19, 2007·Nature Reviews. Cancer·Douglas HedleyCaroline Springer
Feb 19, 2008·Nature Chemical Biology·Dylan W DomailleChristopher J Chang
May 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Omar ZurkiyaXiaoping Hu
Jul 1, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christian Plathow, Wolfgang A Weber
Jul 2, 2008·Nature Reviews. Drug Discovery·Jürgen K WillmannSanjiv S Gambhir
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Michael T McMahonPeter C M van Zijl
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Phillip Zhe SunA Gregory Sorensen
Oct 30, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alex X LiRobert Bartha
Nov 19, 2008·Nature Clinical Practice. Oncology·Shahriar S YaghoubiSanjiv S Gambhir
Dec 18, 2008·Chemical Reviews·Thierry Brotin, Jean-Pierre Dutasta
Jan 23, 2009·Nature Methods·Damian J WallaceMazahir T Hasan

❮ Previous
Next ❯

Citations

Oct 18, 2016·Topics in Magnetic Resonance Imaging : TMRI·Michael T McMahon, Assaf A Gilad
Jan 21, 2017·International Journal of Molecular Sciences·Ethel J Ngen, Dmitri Artemov
Nov 16, 2017·Scientific Reports·Rohan D A AlvaresHai-Ling M Cheng
Feb 19, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Assaf A Gilad, Mikhail G Shapiro
Nov 28, 2020·Scientific Reports·Or PerlmanChristian T Farrar
Sep 9, 2020·Analytical Chemistry·Serge D ZemerovIvan J Dmochowski
Dec 4, 2019·Bioconjugate Chemistry·Harun F OzbakirArnab Mukherjee
Jul 12, 2016·Molecular Pharmaceutics·Ethel J NgenAssaf A Gilad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Guanshu LiuPeter C M van Zijl
Applied Microbiology and Biotechnology
Heinz Neumann, Petra Neumann-Staubitz
© 2022 Meta ULC. All rights reserved