Molecular epidemiologic characterization of a clustering HCV infection caused by inappropriate medical care in Heyuan City of Guangdong, China

PloS One
Yi-Qun KuangPeng Lin

Abstract

From November 2011 to January 2012, a number of clustering cases of HCV infection were reported in Zijin County, Heyuan City, Guangdong, China. Most patients in the clustering cases suspected that they could be infected due to inappropriate medical care in the clinic located at the Xiangshui road. However, the molecular epidemiology of the clustering cases remains unknown. The residents, living at Xiangshui Road, with HCV antibody positive reported from 2011 and 2012 were recruited. A survey of the HCV infected individuals from the clustering cases was conducted. Each participant underwent a questionnaire defining demographic characteristics and health care history. HCV serological test and viral load test were performed to confirm the infection status. Molecular phylogenetic analysis and Bayesian coalescence analysis were conducted to further confirm the HCV subtype distribution and to reconstruct the associated demographic history and time-scaled phylogeny among the clustering cases. The molecular phylogenetic analysis revealed that only two HCV subtypes, 2a and 6a, were found among the clustering cases. There was no close HCV subtype evolutionary relation was observed among patients from the same family. The 6a cluster showe...Continue Reading

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Citations

Nov 26, 2015·Gastroenterology Clinics of North America·Norah J Shire, Kenneth E Sherman

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Datasets Mentioned

BETA
JX194813-JX195062
Y12083
AY859526

Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

jModelTest
FigTree
Clustal X
GraphPad
Tracer
Sequencher
TreeAnnotator
MEGA

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