PMID: 11921190Mar 29, 2002Paper

Molecular epidemiologic studies of polycyclic aromatic hydrocarbon-DNA adducts and breast cancer

Environmental and Molecular Mutagenesis
A RundleF P Perera

Abstract

We review our studies on the role of polycyclic aromatic hydrocarbon (PAH)-DNA adducts in breast cancer. Additionally we report on analyses of the reliability of the scoring procedures used with immunohistochemical assay for PAH-DNA adducts and of potential bias arising from the use of benign breast disease (BBD) controls. We conducted a case-control study utilizing two control groups: BBD controls who donated tissue and blood samples, and healthy controls who donated blood samples. In comparisons of tumor tissue from cases and benign tissue from BBD controls, increasing adduct levels were significantly associated with case-control status [odds ratio (OR) = 2.40, 95% confidence interval (CI) 1.18-4.92], whereas in comparisons of nontumor tissue from cases and benign tissue from BBD controls the association was nonsignificant (OR = 1.97, 95% CI 0.94-4.17). We also show among cases, but not among BBD controls, that the GSTM1 null genotype is associated with increased adduct levels in breast tissue. Our reliability study found the scoring procedures used with the immunohistochemical assay to have high reliability, 0.93 in nontumor, 0.82 in tumor, and 0.74 in benign tissues. However, we found that the technician significantly contr...Continue Reading

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Citations

Mar 18, 2004·Breast Cancer Research and Treatment·Yvonne Marie Coyle
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nora L NockBenjamin A Rybicki
Feb 18, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kyoung-Ho LeeDaehee Kang
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Fariba SalehiKristan J Aronson
Nov 4, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Valentina GalloPaolo Vineis
Jul 11, 2006·Mutation Research·Andrew Rundle
Sep 13, 2005·Cancer Letters·Benjamin A RybickiAndrew Rundle
May 25, 2006·International Journal of Cancer. Journal International Du Cancer·Jolanta LissowskaMontserrat García-Closas
May 16, 2007·Cancer·Julia Green BrodyRuthann A Rudel
Apr 22, 2005·Journal of Cellular Biochemistry·Stephen A MurrayZhi-Xiong Jim Xiao
Aug 3, 2016·Iranian Journal of Cancer Prevention·Andrew GlushkovSvetlana Ragozhina
Dec 18, 2004·Cancer Research·Benjamin A RybickiDeliang Tang
Aug 4, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kumar Ganesan, Baojun Xu

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