Molecular epidemiological analysis of quinolone-resistant Escherichia coli causing bacteremia in neutropenic patients with leukemia in Korea

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
J H YooD J Kim

Abstract

We analyzed an outbreak of Escherichia coli bacteremia in eight patients with leukemia in a hematology-oncology unit from July to September 1994. The antibiograms and genotypic patterns of the isolates were different, thus suggesting that the outbreak did not originate from a single clone. However, all the isolates were resistant to quinolones, which led us to examine the microbiological records from 1992 to 1994. The incidence of quinolone-resistant E. coli bacteremia in the hematology-oncology unit ranged from 81.8% to 94.6% during this period. We then analyzed 36 more isolates recovered from late 1994 to 1995. Field inversion gel electrophoresis patterns of these isolates were also different. Analysis of the quinolone resistance determining region in gyrA revealed that all the isolates had a double mutation in gyrA. In conclusion, quinolone-resistant E. coli could be an emerging threat to neutropenic patients with leukemia who receive a quinolone prophylactically, and attention must be paid to this trend of resistance.

References

Apr 28, 1994·The New England Journal of Medicine·A ComettaM P Glauser

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Citations

Feb 27, 2009·Medizinische Klinik·Fuat H SanerChristoph E Broelsch
Feb 17, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·W V KernR Marre
Nov 6, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M ArnanF Gudiol
Nov 30, 2000·Current Infectious Disease Reports·L B Rice, R A Bonomo
Oct 29, 2000·International Journal of Antimicrobial Agents·S H Zinner
Mar 18, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D L PatersonV L Yu
Aug 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B A CollinR Ramphal
May 6, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L Paterson
May 27, 2014·Infectious Disease Clinics of North America·Lilian M Abbo, Ella J Ariza-Heredia
Nov 24, 2004·International Journal of Antimicrobial Agents·Silja MentulaEija Könönen
Dec 12, 2012·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Rachel M GreenblattEbbing Lautenbach
Feb 8, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Cheol-In KangKang-Won Choe
Jan 3, 2009·Journal of Korean Medical Science·Su-Mi ChoiWan-Shik Shin
Oct 30, 1999·Antimicrobial Agents and Chemotherapy·J GarauA Ruíz-Bremón

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