Molecular epidemiological characterization and health burden of thalassemia in Jiangxi Province, P. R. China

PloS One
Min LinLi Ye Yang


Thalassemia is the most common inherited disease in southern China. However, this disorder is usually ignored by Jiangxi provincial health system and government due to lack of epidemiological data. A total of 9489 samples from Hakka Han and Gan-speaking Han in three geographical areas of Jiangxi Province were analyzed for both complete blood cell (CBC) count and reverse dot blot (RDB) gene chip for thalassemia. 1182 cases of suspected thalassemia carriers with microcytosis (MCV<82 fL) were found by CBC count, and were tested by RDB gene chip to reveal a total of 594 mutant chromosomes, including 433 α-thalassemia mutant chromosomes and 172 β-thalassemia mutant chromosomes. Our results indicated a higher prevalence of thalassemia with the heterozygote frequency of 9.49% in southern Jiangxi province, whereas the low frequency was found in middle (3.90%) and northern Jiangxi (2.63%). Based on the epidemiological data, the estimated numbers of pregnancies in Jiangxi province in which the fetus is at risk for β-thalassemia major or intermedia, Bart's hydrops fetalis and Hb H disease are 34 (95% CI, 16 to 58), 79 (95% CI, 50 to 114) and 39 (95% CI, 27 to 58) per year, respectively. We suggested that prevention network of thalassemia ...Continue Reading


Oct 1, 1987·Journal of Medical Genetics·Y T Zeng, S Z Huang
Jul 21, 1998·Annals of the New York Academy of Sciences·M Angastiniotis, B Modell
Aug 24, 2000·The New England Journal of Medicine·F E ChenV Chan
Jan 23, 2002·Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen·S K Das, G Talukder
Nov 4, 2004·Biochemical and Biophysical Research Communications·Keiko Akasaka-ManyaTamao Endo
Aug 20, 2008·International Journal of Laboratory Hematology·H-J LinJ-G Chang
Feb 24, 2009·Blood Cells, Molecules & Diseases·Ella T NkhomaErnest Beutler
Jul 14, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Supatra SirichotiyakulTheera Tongsong
Nov 12, 2009·Haematologica·Raffaella OrigaRenzo Galanello
May 25, 2010·Orphanet Journal of Rare Diseases·Renzo Galanello, Raffaella Origa
Feb 23, 2011·International Journal of Laboratory Hematology·G FucharoenS Fucharoen
May 24, 2011·Hemoglobin·Su-Ching LiuChien-Yu Lin
Aug 9, 2013·Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics·Liang-pu XuYuan Lin


Oct 1, 2019·Molecular Genetics & Genomic Medicine·Haoxian LiXiaofang Sun
Sep 12, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Wenqian CaiXijiang Hu
Oct 28, 2019·Journal of Clinical Pathology·Jianlong ZhuangShuhong Zeng
Sep 5, 2020·European Journal of Haematology·Antonis KattamisVip Viprakasit
May 23, 2019·BMC Medical Genetics·Zhuo YangBing Han

Related Concepts

Complete Blood Count
Repeated Rounds of Survey
Thalassemia Minor
Cost of Illness
Genetic Epidemiology
Healthy Volunteers
Blood Cells
Southern Blot Assay (Procedure)
Western Blotting

Related Feeds


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.