Molecular epidemiological study of dengue virus type 1 in Taiwan

Journal of Medical Virology
Kao-Pin HwangKuei-Hsiang Lin

Abstract

Taiwan has experienced several major outbreaks of dengue (DEN) virus since 1981. The predominant virus type involved has been dengue virus type one (DEN-1), which first appeared in 1987. To understand the molecular epidemiology of this virus, 15 strains of DEN-1 isolated during 1987-1991 and 1994-1995, including 11 epidemic strains, two sporadic strains, and two imported strains have been studied. Fragments of 490 nucleotides (nt) from the E/NS1 junction were amplified by reverse transcription-polymerase chain reaction and the nt sequences were determined. Of the 490 nt of the E/NS1 junction, 240 nt (nt 2282-2521) were aligned and compared. Nucleotide substitutions were found at 54 positions among 15 isolates. Most nt changes were synonymous substitutions, and only three amino acid changes were found. A total of 61 strains isolated worldwide were analyzed by the Neighbor-joining method, and separated phylogenetically into three distinct genotypes, I-III. Genotype I comprised isolates from Japan and Hawaii collected in the 1940s. Genotype II included most strains isolated from Asia in 1977-1995. Genotype III consisted of isolates from three continents in 1964-1995: Asia, the Americas, and Africa. Genotype III was divided further...Continue Reading

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Citations

Sep 15, 2010·Virology Journal·Jairo A MendezJuan C Gallego-Gomez
Mar 13, 2012·Virology Journal·Jairo A MéndezJuan C Gallego-Gomez
Jun 3, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·J A PatilD Cecilia
Mar 29, 2014·Epidemiology and Infection·P V BardeN Singh
Mar 23, 2005·FEMS Immunology and Medical Microbiology·Rong-Fu ChenKuender D Yang
Oct 1, 2015·Emerging Microbes & Infections·Sheng-Fan WangYi-Ming Arthur Chen

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