PMID: 8947294Nov 20, 1996Paper

Molecular epidemiology and MT-2 cell tropism of Russian HIV type 1 variant

AIDS Research and Human Retroviruses
T LeitnerJ Albert

Abstract

Twenty-two HIV-1-infected Russian individuals were studied to gain better insight on the genetic and biological characteristics of HIV-1 variants present in Russia. The V3 domain of the HIV-1 envelope was directly sequenced from cultured peripheral blood mononuclear cells (PBMCs). Phylogenetic analyses were used to determine the HIV-1 genetic subtype and to study transmission patterns. Virus isolates were obtained from PBMCs and the biological phenotype was determined by coculture with MT-2, CEM, and Jurkat-tat cells. Twelve homo- and bisexual men carried subtype B variants, whereas 6 heterosexually infected individuals carried subtype F virus. A heterosexual man infected in the Ivory Coast and a nosocomially infected young female carried subtype A and G virus, respectively. Interestingly, phylogenetic analyses suggested that subtype B may have entered Russia on at least four occasions and, even more surprisingly, that the relatively rare subtype F has entered Russia on at least three occasions. Two suspected transmission clusters of subtype F were supported by the phylogenetic analyses, whereas one suspected subtype B transmission cluster was not. Positively charged amino acids in positions 311 and 325 of V3 loop have been sho...Continue Reading

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Citations

Jul 31, 2002·Transfusion·Rigmor ThorstenssonSören Andersson
Jan 12, 2001·AIDS Research and Human Retroviruses·M OrtizA García-Sáiz
Feb 15, 2001·AIDS Research and Human Retroviruses·V UstinaJ Albert
Sep 18, 2001·AIDS Research and Human Retroviruses·I PandreaC Apetrei
Sep 18, 2001·AIDS Research and Human Retroviruses·M ReinisJ K Carr
Jun 25, 2002·AIDS Research and Human Retroviruses·Karl LjungbergThomas Leitner
Aug 12, 2003·AIDS Research and Human Retroviruses·Eleonor BrandinJan Albert
Nov 11, 1999·AIDS Research and Human Retroviruses·A FerdatsJ Albert
Jun 5, 1999·AIDS Research and Human Retroviruses·K W SagoeA Sönnerborg
Aug 26, 1998·AIDS Research and Human Retroviruses·V A NovitskyM Essex
Mar 30, 2005·AIDS Research and Human Retroviruses·Ann AtlasAnnette Alaeus
Feb 1, 2007·AIDS Research and Human Retroviruses·Helene MensTerese L Katzenstein
Dec 7, 2006·AIDS Research and Human Retroviruses·Tatiana SmolskayaMika Salminen
May 29, 2007·AIDS Research and Human Retroviruses·Tina V MadsenLouise B Jørgensen
Aug 2, 2008·AIDS Research and Human Retroviruses·Terese L KatzensteinJan Gerstoft
May 30, 2008·AIDS Research and Human Retroviruses·Balthazar M NyombiCarol Holm-Hansen
Dec 1, 2009·AIDS Research and Human Retroviruses·Aurora Fernández-GarcíaMichael M Thomson
Jan 14, 2011·AIDS Research and Human Retroviruses·Ana RevillaMichael M Thomson
Nov 5, 2011·AIDS Research and Human Retroviruses·Dace BalodeJan Albert
Feb 1, 1997·AIDS·A AlaeusJ Albert
Jul 14, 1998·AIDS·C ApetreiF Simon
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Aug 13, 2002·AIDS·María Teresa CuevasMichael M Thomson
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