Molecular epidemiology and novel combinations of auxotype, serovar, and plasmid content in tetracycline-resistant Neisseria gonorrhoeae isolated in Canada

Canadian Journal of Microbiology
J R Dillon, M Carballo

Abstract

Between October 1987 and June 1989, 84 isolates of Neisseria gonorrhoeae carrying the TetM resistance determinant (TRNG) were received at the Laboratory Centre for Disease Control, Ottawa, from six Canadian provinces and were characterized into classes based on auxotype, serovar and plasmid content. One-fifth (17/84) of the TRNG were also penicillinase producing (PPNG). The PPNG-TRNG isolates comprised six classes based on auxotype, serovar, and plasmid content. Most (16/17) PPNG-TRNG carried 3.2-MDa beta-lactamase plasmids and the 25.2-MDa TetM-containing plasmid. We report, for the first time, the association of a 4.5-MDa beta-lactamase plasmid with the 25.2-MDa plasmid in a clinical TRNG isolate. Non-PPNG TRNG isolates comprised 11 classes based on auxotype, serovar, and plasmid content, including two previously unreported auxotype-serovar classes, P/IB-26 and P/IB-20.

Citations

Dec 1, 1996·The Journal of Hospital Infection·E G Power
Mar 6, 2004·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Valerie GrecoJo-Anne R Dillon
Aug 1, 1992·Genitourinary Medicine·D M Gascoyne-BinziM Nadarajah
May 16, 1998·Genitourinary Medicine·M J van de LaarB van Klingeren
Jan 30, 2008·The Journal of Antimicrobial Chemotherapy·Mingmin LiaoJo-Anne R Dillon
Aug 24, 2001·Sexually Transmitted Diseases·J A DillonUNKNOWN Caribbean GASP Network. Gonococcal Antimicrobial Surveillance Program
Dec 6, 2002·Sexually Transmitted Diseases·Carolina M MarquezGraciela Borthagaray
Aug 17, 1999·Sexually Transmitted Infections·A TurnerJ P Leeming

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