Molecular epidemiology of adenovirus type 7 in Israel: identification of two new genome types, Ad7k and Ad7d2

Journal of Medical Virology
R AzarE Mendelson

Abstract

The molecular epidemiology of Adenovirus type 7 in Israel was investigated. Fifty-seven adenovirus isolates identified as serotypes 7 or 7a which were recovered from patients in Israel between 1968 and 1995 were analyzed by restriction enzymes digestion using BamHI for primary discrimination and identification of genome types and by six additional enzymes: BstEII, HpaI, BglI, BglII, BclI, and XbaI for confirmation and determination of genomic subtypes. Four digestion patterns were identified with BamHI; one of them was new. Using BstEII, two patterns were obtained, one of them new. Digestion with the other five enzymes yielded known patterns. The analysis revealed four different genomic types and subtypes, which circulated in Israel in different years: subtype 7a1; type 7b, a type with a new BamHI pattern which was designated type 7K, and a subtype with a new BstEII pattern which differed from type 7d by one restriction site and was designated type 7d2. Twenty-two isolates from 1968 through 1975 and from 1984 were Ad7a1. Three isolates from 1973-1974 were Ad7b. Five isolates from 1968 through 1973 were Ad7K and 27 isolates from 1992 through 1995 were Ad7d2. This demonstrates the temporal change in the circulating genome types w...Continue Reading

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Citations

Apr 3, 2002·Emerging Infectious Diseases·Dean D ErdmanLarry J Anderson
Oct 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gregory C GrayDean D Erdman
Jan 23, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Margaret A K RyanMarietta D Malasig
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Apr 10, 2003·Journal of Medical Virology·Yoshifumi IkedaTakeo Ogino
Dec 18, 2021·Seminars in Respiratory and Critical Care Medicine·Joseph P Lynch, Adriana E Kajon

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