Molecular epidemiology of A/H3N2 and A/H1N1 influenza virus during a single epidemic season in the United States.

PLoS Pathogens
Martha I NelsonEdward C Holmes

Abstract

To determine the spatial and temporal dynamics of influenza A virus during a single epidemic, we examined whole-genome sequences of 284 A/H1N1 and 69 A/H3N2 viruses collected across the continental United States during the 2006-2007 influenza season, representing the largest study of its kind undertaken to date. A phylogenetic analysis revealed that multiple clades of both A/H1N1 and A/H3N2 entered and co-circulated in the United States during this season, even in localities that are distant from major metropolitan areas, and with no clear pattern of spatial spread. In addition, co-circulating clades of the same subtype exchanged genome segments through reassortment, producing both a minor clade of A/H3N2 viruses that appears to have re-acquired sensitivity to the adamantane class of antiviral drugs, as well as a likely antigenically distinct A/H1N1 clade that became globally dominant following this season. Overall, the co-circulation of multiple viral clades during the 2006-2007 epidemic season revealed patterns of spatial spread that are far more complex than observed previously, and suggests a major role for both migration and reassortment in shaping the epidemiological dynamics of human influenza A virus.

References

May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·W M FitchP Palese
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y Ina, T Gojobori
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·W M FitchN J Cox
Jan 27, 1999·Bioinformatics·D Posada, K A Crandall
Jan 28, 1999·Proceedings. Biological Sciences·E BonabeauA Flahault
Nov 11, 1999·Molecular Biology and Evolution·R M BushN J Cox
Dec 3, 1999·Science·R M BushW M Fitch
Jan 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A J HayY P Lin
Feb 1, 2002·Journal of Molecular Evolution·Gareth M JenkinsEdward C Holmes
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Mar 28, 2003·Nature·Neil M FergusonRobin M Bush
Nov 19, 2003·European Journal of Epidemiology·Rebecca F GraisGregory E Glass
Jun 26, 2004·Science·Derek J SmithRon A M Fouchier
Sep 16, 2004·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Feb 16, 2005·Archives of Internal Medicine·Lone SimonsenMark A Miller
Feb 4, 2006·JAMA : the Journal of the American Medical Association·Rick A BrightAlexander I Klimov
Mar 3, 2006·PLoS Medicine·Cécile ViboudLone Simonsen
Apr 1, 2006·Science·Cécile ViboudBryan T Grenfell
Dec 5, 2006·PLoS Pathogens·Martha I NelsonEdward C Holmes
Jan 31, 2007·Nature Reviews. Genetics·Martha I Nelson, Edward C Holmes
May 25, 2007·Molecular Biology and Evolution·Lone SimonsenEdward C Holmes
Jun 16, 2007·The Journal of Infectious Diseases·Varough M DeydeAlexander I Klimov
Oct 19, 2007·PLoS Pathogens·Martha I NelsonEdward C Holmes
Oct 19, 2007·Journal of Virology·Yiming BaoDavid Lipman
Apr 19, 2008·Science·Colin A RussellDerek J Smith
Jun 23, 2011·PLoS Pathogens·Martha I NelsonMarie Gramer

❮ Previous
Next ❯

Citations

May 18, 2013·Future Virology·Vivien G DuganElodie Ghedin
Aug 26, 2014·Annals of the American Thoracic Society·Cornelius J ClancyM Hong Nguyen
Oct 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Edward C Holmes
Sep 5, 2009·The Journal of Clinical Investigation·Edward C Holmes
Oct 27, 2009·PLoS Pathogens·Alice Carolyn McHardy, Ben Adams
Oct 27, 2009·PLoS Computational Biology·Edward C Holmes, Bryan T Grenfell
Dec 24, 2009·PLoS Currents·Martha NelsonKelly Henrickson
Jan 6, 2010·PloS One·Nicole CreanzaJoel E Cohen
Feb 5, 2010·Journal of Clinical Microbiology·Hassan ZaraketHiroshi Suzuki
Feb 12, 2010·Journal of the Royal Society, Interface·J Conrad StackBryan T Grenfell
Dec 15, 2010·The Journal of Infectious Diseases·Tiffany G SheuLarisa V Gubareva
Feb 6, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Cécile ViboudEdward C Holmes
Jul 31, 2014·PloS One·Marina Escalera-ZamudioUNKNOWN Members of Colegio de Pediatría del Estado de Veracruz
Dec 14, 2011·Molecular Biology and Evolution·Jennifer A TomMarc A Suchard
Aug 30, 2012·The Journal of Infectious Diseases·Xiaowen ChengJinquan Cheng
Mar 16, 2011·Yi chuan = Hereditas·Chang-Zheng Dong
Oct 2, 2013·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·K HoschlerM Zambon
Jan 3, 2012·Theoretical Population Biology·Adam J Kucharski, Julia R Gog
Oct 5, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·John-Sebastian EdenPeter A White
Jan 17, 2015·ELife·Dhanasekaran VijaykrishnaIan G Barr
Aug 24, 2013·PLoS Computational Biology·Chiara PolettoAlessandro Vespignani
Jun 15, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Karen Ka Yin WongWilliam Rawlinson
Jun 9, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Alessandra FalchiLaurent Andreoletti
Mar 24, 2017·Bioinformatics·Erik L ClarkeDustin Brisson
Sep 1, 2017·Journal of Virology·Christopher B Brooke
Apr 18, 2014·Journal of Virology·Hui TaoAnice C Lowen
Jan 13, 2018·PLoS Pathogens·Jemma L GeogheganEdward C Holmes
Aug 2, 2018·PloS One·Agustiningsih AgustiningsihDavid Handojo Muljono
Jul 1, 2009·Nature Reviews. Genetics·Oliver G Pybus, Andrew Rambaut
Nov 12, 2009·Influenza and Other Respiratory Viruses·Varough DeydeLarisa Gubareva

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylation
nucleic acid extraction

Software Mentioned

PAUP
PAUP *
MODELTEST
MacClade

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.