Molecular Epidemiology of Brucella abortus in Northern Ireland-1991 to 2012

PloS One
Adrian AllenAdrian Whatmore

Abstract

Brucellosis is the most common bacterial zoonoses worldwide. Bovine brucellosis caused by Brucella abortus has far reaching animal health and economic impacts at both the local and national levels. Alongside traditional veterinary epidemiology, the use of molecular typing has recently been applied to inform on bacterial population structure and identify epidemiologically-linked cases of infection. Multi-locus variable number tandem repeat VNTR analysis (MLVA) was used to investigate the molecular epidemiology of a well-characterised Brucella abortus epidemic in Northern Ireland involving 387 herds between 1991 and 2012. MLVA identified 98 unique B. abortus genotypes from disclosing isolates in the 387 herds involved in the epidemic. Clustering algorithms revealed the relatedness of many of these genotypes. Combined with epidemiological information on chronology of infection and geographic location, these genotype data helped to identify 7 clonal complexes which underpinned the outbreak over the defined period. Hyper-variability of some VNTR loci both within herds and individual animals led to detection of multiple genotypes associated with single outbreaks. However with dense sampling, these genotypes could still be associated ...Continue Reading

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Citations

Feb 6, 2017·BMC Microbiology·Giuliano GarofoloJeffrey T Foster
Apr 15, 2020·PLoS Neglected Tropical Diseases·Marcela Suárez-EsquivelCaterina Guzmán-Verri
Apr 9, 2020·Veterinary Medicine and Science·Nour H Abdel-HamidAbeer A Shehata
Nov 14, 2018·Frontiers in Veterinary Science·Zhi-Guo LiuHai Jiang
Dec 24, 2020·The Veterinary Quarterly·Sandip Kumar KhuranaWanpen Chaicumpa
Oct 24, 2020·International Journal of Molecular Sciences·Marcela Suárez-EsquivelCaterina Guzmán-Verri
Feb 9, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Adrian R AllenJeffrey T Foster
Apr 20, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Adrian M Whatmore, Jeffrey T Foster

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Methods Mentioned

BETA
genotyping
PCR
electrophoresis

Software Mentioned

Bionumerics
MAPINFO
- Spatial Cluster Analysis
AHVLA
STATA
MLVA
ArcGIS
Multi
eBurst
Burst

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