Molecular epidemiology of carbapenem non-susceptible Acinetobacter nosocomialis in a medical center in Taiwan

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Ya-Sung YangFeng-Yee Chang

Abstract

The mechanism by which carbapenem non-susceptible Acinetobacter nosocomialis (CNSAN) is disseminated is rarely described in the literature. In this study, we delineated the molecular epidemiology of CNSAN isolated from patients in a medical center in Taiwan. Fifty-four non-duplicate bloodstream isolates of CNSAN were collected at the Taipei Veterans General Hospital between 2001 and 2007. Pulsed-field gel electrophoresis (PFGE) was performed to determine their clonal relationship. Carbapenem-resistance genes and associated genetic structures were detected by polymerase chain reaction (PCR) mapping. Southern hybridization was performed to determine the plasmid location of carbapenem-resistance genes. Transmissibility of these genes to Acinetobacterbaumannii was demonstrated by conjugation tests. The overall carbapenem non-susceptibility rate among A. nosocomialis isolates during the study period was 21.6% (54/250). PFGE revealed three major pulsotypes: H (n=23), I (n=10), and K (n=8). The most common carbapenem-resistance gene was blaOXA-58 (43/54, 79.6%), containing an upstream insertion sequence IS1006 and a truncated ISAba3 (IS1006-ΔISAba3-like-blaOXA-58). All isolates belonging to the pulsotypes H, I, and K carried plasmid l...Continue Reading

References

May 3, 2003·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Maria Virginia Villegas, Alan I Hartstein
Oct 27, 2004·The Journal of Hospital Infection·J F TurtonT L Pitt
Mar 28, 2006·International Journal of Antimicrobial Agents·Neil WoodfordDavid M Livermore
Aug 3, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L Poirel, P Nordmann
Nov 17, 2006·Journal of Clinical Microbiology·Jubelle K ValenzuelaJon Iredell
May 10, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T-L ChenW-L Cho
Jul 11, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Dror MarchaimYehuda Carmeli
Jan 16, 2008·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Jul 16, 2008·Clinical Microbiology Reviews·Anton Y PelegDavid L Paterson
Dec 2, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L-Y HuangL K Siu
Mar 3, 2010·Antimicrobial Agents and Chemotherapy·Yu-Chi LinShu-Ying Li
Jan 5, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yu-Chung ChuangShan-Chwen Chang
Mar 12, 2011·The Journal of Antimicrobial Chemotherapy·Nabil KarahUNKNOWN Norwegian Study Group of Acinetobacter
Mar 30, 2011·Antimicrobial Agents and Chemotherapy·Pierre BogaertsYouri Glupczynski
Aug 25, 2011·The Journal of Antimicrobial Chemotherapy·Masaki YamamotoSatoshi Ichiyama
Oct 15, 2011·International Journal of Antimicrobial Agents·Young Kyoung ParkKwan Soo Ko
Nov 25, 2011·International Journal of Antimicrobial Agents·Marie Kempf, Jean-Marc Rolain
Dec 2, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S FigueiredoP Nordmann
Apr 13, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yi-Tzu LeeChang-Phone Fung
Jul 11, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Shu-Chen KuoChang-Phone Fung
Sep 13, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Y-T LeeC-P Fung

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