Molecular epidemiology of carbapenem-resistant Acinetobacter spp. from XiangYa Hospital, in Hunan Province, China

Journal of Basic Microbiology
Zhenhua ChenYuanyuan Liu

Abstract

Carbapenem-resistant Acinetobacter baumannii has been known as an opportunistic pathogen that causes a variety of illness worldwide. In this study, we characterize the molecular epidemiology of 174 non-repetitive clinical isolates of A. baumannii collected from January to June 2009 from Xiangya Hospital, in Hunan Province, China, including an outbreak period of A. baumannii. These 174 isolates harbored A. baumannii intrinsic gene OXA-51. They were resistant to multiple antibiotics with resistance rates as 49.4% to imipenem, 48.3% to meropenem, 46.6% to ampicillin-sulbactam, 6.9% to cefoperazone-sulbactam, and 6.3% to minocycline. 74 out of 174 isolates were identified as carbapenemase-producing strains, among which bla(OXA-23) gene was found in 71 isolates. These 74 carbapenemase expression strains could be divided into four genotypes by enterobacterial repetitive intergenic consensus (ERIC)-PCR, with 19, 17, 33 and 5 clones in each group. We also found four imipenem resistant isolates carrying OXA-23 gene without showing carbapenemase phenotype. Our findings show that the bla(OXA-23) gene is the common carbapenemase gene among carbapenem-resistant Acinetobacter spp. isolates, suggesting that clonal spread of carbapenemase-prod...Continue Reading

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Citations

Jul 6, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Xiao-Tian DaiPei-Yuan Xia
Feb 26, 2015·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Witchuda KamolvitDavid L Paterson
Nov 20, 2018·Polish Journal of Microbiology·Meijie JiangShulin Han

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