Molecular epidemiology of Clostridium difficile infections in children: a retrospective cohort study

Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
Larry K KociolekDale N Gerding

Abstract

The molecular epidemiology of pediatric Clostridium difficile infection (CDI) is poorly understood. We aimed to identify the restriction endonuclease analysis (REA) groups causing CDI and to determine risk factors and outcomes associated with CDI caused by epidemic strains in children. Retrospective cohort study. Inpatients and outpatients >1 year old receiving care between December 2012 and December 2013. An academic children's hospital in Chicago, Illinois. C. difficile PCR-positive stools were cultured, and C. difficile isolates were typed by REA. REA of isolates from patients with multiple CDIs was performed to differentiate relapse (infection with same strain) from reinfection (different strains) irrespective of time between CDIs. A total of 189 CDIs occurred among 145 patients. REA groups were widely distributed. The BI/NAP1/027 strain caused CDI in only 1 patient. DH/NAP11/106, the predominant epidemic strain identified, was associated with the use of third- or fourth-generation cephalosporins (risk ratio [RR], 3.2; 95% confidence interval [CI], 1.1-9.9; P=.04). CDI relapse commonly occurred up to 20 weeks later. Compared with CDI caused by non-DH/NAP11/106 strains, CDI caused by DH/NAP11/106 was more likely to result in...Continue Reading

References

Oct 1, 1989·Journal of Clinical Microbiology·C R ClabotsD N Gerding
Dec 3, 2005·The New England Journal of Medicine·L Clifford McDonaldDale N Gerding
Feb 1, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·L Clifford McDonaldUNKNOWN Ad Hoc Clostridium difficile Surveillance Working Group
Oct 11, 2007·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Lacey BensonNalini Singh
Oct 31, 2008·The New England Journal of Medicine·Ciarán P Kelly, J Thomas LaMont
Apr 24, 2009·The Journal of Hospital Infection·F SundramA Scourfield
Sep 29, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jaime BelmaresDale N Gerding
Mar 31, 2010·Emerging Infectious Diseases·Marya D ZilberbergClifford McDonald
Jul 9, 2010·Clinical Microbiology Reviews·J FreemanM H Wilcox
Jan 5, 2011·Archives of Pediatrics & Adolescent Medicine·Cade M NylundMitchell B Cohen
Aug 11, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Stephanie R BlackSusan I Gerber
Oct 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mini KambojKent A Sepkowitz
Oct 28, 2011·The Pediatric Infectious Disease Journal·Jason KimTheoklis Zaoutis
Dec 8, 2011·The Journal of Antimicrobial Chemotherapy·Marjolein P M HensgensEd J Kuijper
Oct 12, 2012·Journal of Clinical Microbiology·Jane W MarshLee H Harrison
Feb 15, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sahil KhannaDarrell S Pardi
May 21, 2013·Journal of the Pediatric Infectious Diseases Society·Pranita D Tamma, Thomas J Sandora
Oct 31, 2013·The Pediatric Infectious Disease Journal·Sarah Tschudin-SutterTrish M Perl
Apr 8, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stuart Johnson
Jun 11, 2014·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Sarah Tschudin-SutterTrish M Perl

❮ Previous
Next ❯

Citations

Dec 20, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Dale N Gerding
May 24, 2015·The Journal of Pediatrics·Larry K KociolekDale N Gerding
Oct 22, 2016·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Vivian G LooMark A Miller
Jan 26, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Larry K KociolekEgon A Ozer
Nov 8, 2017·Current Infectious Disease Reports·Jason A Clayton, Philip Toltzis
Oct 30, 2015·Journal of Clinical Microbiology·Larry K Kociolek, Dale N Gerding
Jan 22, 2019·Journal of Pediatric Hematology/oncology·Zachary I WillisMaria C Di Pentima
Jul 25, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Elisa OchfeldLarry K Kociolek
Jun 30, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Larry K KociolekCiaran P Kelly
Mar 24, 2016·World Journal of Gastroenterology : WJG·Lynne Vernice McFarlandShan Goh
May 8, 2019·Epidemiology and Infection·M AlfayyadhA Cook
Apr 30, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Aakash B BalajiLarry K Kociolek
Feb 3, 2018·Microbes and Infection·Larry K KociolekEgon A Ozer
Jul 8, 2021·Current Opinion in Infectious Diseases·Larry K KociolekHayden T Schwenk
Nov 19, 2021·Journal of the Pediatric Infectious Diseases Society·Matthew M Sattler, Jonathan D Crews
Nov 19, 2021·Journal of the Pediatric Infectious Diseases Society·Alexa K SemonJoseph P Zackular
Nov 19, 2021·Journal of the Pediatric Infectious Diseases Society·Sicilia Perumalsamy, Thomas V Riley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Konstantinos Z VardakasMatthew E Falagas
Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
T ScardinaS Johnson
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Iris FigueroaDale N Gerding
© 2021 Meta ULC. All rights reserved