Molecular epidemiology of dengue in a setting of low reported endemicity: Kupang, East Nusa Tenggara province, Indonesia.

Transactions of the Royal Society of Tropical Medicine and Hygiene
Rahma F HayatiR Tedjo Sasmono


Most regions in Indonesia experience annual dengue epidemics. However, the province of East Nusa Tenggara has consistently reported low incidence. We conducted a dengue molecular epidemiology study in Kupang, the capital of the province. Dengue patients were recruited from May 2016 to September 2017. Dengue virus (DENV) screening was performed using NS1 and immunoglobulin G (IgG)/IgM detection. Serotype was determined using reverse transcription polymerase chain reaction and the envelope genes were sequenced to infer the genetic identity and phylogeny. From 119 patients, dengue was confirmed in 62 (52%). Compared with official data, underreporting of dengue incidence was observed. The majority (36%) of patients were children <10 y of age. Most patients (80%) experienced mild fever. All serotypes were detected, with DENV-3 as the predominant (57%). Kupang DENV-1 isolate was classified as genotype IV, an old and endemic strain, DENV-2 as cosmopolitan, DENV-3 as genotype I and DENV-4 as genotype II. Most isolates showed relatively low evolutionary rates and are closely related with strains from Bali and Timor Leste. The low dengue incidence was most likely caused by sustained local circulation of endemic viruses. This study provid...Continue Reading


Jan 1, 1994·The Journal of General Virology·R S LanciottiD W Trent
Sep 18, 1997·The Journal of General Virology·R S LanciottiD W Trent
Jul 17, 1998·Clinical Microbiology Reviews·D J Gubler
Jul 18, 2002·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·María G GuzmánScott B Halstead
Dec 17, 2002·Virology·Ana P GoncalvezFerdinando Liprandi
Mar 2, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Agus SuwandonoPatrick J Blair
Mar 18, 2006·The Journal of Infectious Diseases·Panisadee AvirutnanPrida Malasit
Nov 13, 2007·BMC Evolutionary Biology·Alexei J Drummond, Andrew Rambaut
Apr 15, 2008·Molecular Biology and Evolution·Vladimir N MininMarc A Suchard
Feb 11, 2009·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ravindran ThayanShamala Devi
Apr 21, 2009·Methods in Molecular Biology·Kazutaka KatohHiroyuki Toh
May 23, 2009·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Scott C Weaver, Nikos Vasilakis
Mar 13, 2010·PloS One·Morgan N PriceAdam P Arkin
Nov 17, 2010·Nature Reviews. Microbiology·Maria G GuzmanRosanna W Peeling
Oct 14, 2011·Viruses·Rubing Chen, Nikos Vasilakis
Jan 10, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Raquel L CostaCarlos G Schrago
Aug 1, 2012·Nature Methods·Diego DarribaDavid Posada
Oct 25, 2012·Emerging Infectious Diseases·David WarrilowAlyssa T Pyke
Feb 26, 2013·PLoS Neglected Tropical Diseases·Donald S ShepardYara A Halasa
Apr 9, 2013·Nature·Samir BhattSimon I Hay
Jul 23, 2013·PLoS Neglected Tropical Diseases·Gilberto A SantiagoJorge L Muñoz-Jordán
May 27, 2014·Japanese Journal of Infectious Diseases·Tomohiro KotakiMasanori Kameoka
Jun 12, 2014·Journal of Infection in Developing Countries·Roy NusaR Tedjo Sasmono
Nov 5, 2014·BMC Infectious Diseases·Shiran Ajith ParanavitaneGathsaurie Neelika Malavige
Mar 19, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·R Tedjo SasmonoMark J Schreiber
May 25, 2016·Pathogens and Global Health·Sotianingsih HaryantoR Tedjo Sasmono
May 23, 2017·PLoS Neglected Tropical Diseases·Dewi MegawatiR Tedjo Sasmono
Jun 3, 2017·PloS One·Puspa WardhaniR Tedjo Sasmono
Jun 16, 2017·PLoS Neglected Tropical Diseases·Ari PrayitnoSri Rezeki Hadinegoro
Jan 6, 2018·Parasites & Vectors·Kinley WangdiSusana Vaz Nery
Apr 29, 2018·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·S PollettR G Jarman

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