Molecular Epidemiology of Echovirus 18 Circulating in Mainland China from 2015 to 2016

Virologica Sinica
Xiangpeng ChenZheng-de Xie

Abstract

Echovirus 18 (E18), a serotype of Enterovirus B (EV-B) species, is an important pathogen in aseptic meningitis. E18 had rarely been detected in mainland China, but became the predominant pathogen associated with viral encephalitis (VE) and meningitis in Hebei province for the first time in 2015. To investigate the molecular epidemiology and genetic characteristics of E18 in mainland China, sixteen E18 strains from patient throat swabs with hand, foot, and mouth disease (HFMD) in six provinces in China collected between 2015 and 2016, and four E18 strains isolated from 18 patient cerebrospinal fluid specimens with VE in Hebei Province in 2015 were obtained and sequenced. Combined with the sequences from the GenBank database, we performed an extensive genetic analysis. Phylogenetic analysis of VP1 gene sequences revealed that all E18 strains from mainland China after 2015 belonged to subgenotype C2. There were no obvious specific differences in phylogenetic and variation analyses of E18 genome sequences between HFMD and VE/meningitis strains. Potential multiple recombination may have occurred in the 5'-untranslated region and in the P2 and P3 nonstructural protein-encoding regions of E18 strains from China. The current E18 strain...Continue Reading

References

Jan 27, 1999·Bioinformatics·D Posada, K A Crandall
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yongning HeMichael G Rossmann
Dec 4, 2004·Reviews in Medical Virology·Alexander N Lukashev
Oct 1, 2010·The Pediatric Infectious Disease Journal·Shih-Min WangChing-Chuan Liu
Mar 1, 2012·Molecular Biology and Evolution·Alexei J DrummondAndrew Rambaut
Jan 16, 2014·The Journal of General Virology·Alexander N LukashevChristian Drosten
Sep 4, 2015·MMWR. Morbidity and Mortality Weekly Report·Glen R AbediSusan I Gerber

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Citations

Mar 11, 2020·Frontiers in Microbiology·Bo-Shiun ChenShin-Ru Shih
Jun 26, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jingjing LiMei Zeng

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PCR

Software Mentioned

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Evolutionary Analysis Sampling Trees ( BEAST
jModelTest
Simplot
Bayesian
MrBayes
Sequencher
BEAST
Metcalf
BioEdit

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