Molecular epidemiology of HIV-1 subtype B, CRF01_AE, and CRF07_BC infection among injection drug users in Taiwan

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Yen-Ju ChenYi-Ming Arthur Chen

Abstract

An explosive outbreak of HIV-1 circulating recombinant form (CRF) 07_BC among injection drug users (IDUs) in Taiwan was first reported in 2004 and reach the peak in 2005. The objectives of this study were to investigate the molecular epidemiology of different HIV-1 subtypes and their associated risk factors among Taiwanese IDUs in 2004 and 2005. Questionnaires and blood specimens were collected from inmates from 4 detention centers and 2 prisons. HIV-1 subtypes were determined using nested polymerase chain reactions with multiplex primers and phylogenetic analyses. A case-control study was conducted to elucidate risk factors associated with CRF07_BC infection. A total of 93.8%, 4%, and 2.2% of 451 inmates with IDU history were infected with CRF07_BC, subtype B, and CRF01_AE, respectively. Besides CRF07_BC, a new outbreak of CRF01_AE infection was identified among IDUs from central region. Multivariate analysis showed that sharing dissolved heroine solution [odds ratio (OR) = 17.2], sharing syringes (OR = 34), number of persons sharing syringes (2 vs. 1, OR = 3.1), and lower educational level (OR = 2.3) were risk factors associated with CRF07_BC infection. Sharing dissolved heroine solution is a neglected risk factor associated ...Continue Reading

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Citations

Aug 20, 2011·Lancet·Shu-Yu LyuYi-Ming Arthur Chen
Sep 3, 2010·PloS One·Jonathan Hon-Kwan ChenWing-Cheong Yam
Feb 19, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ying-Hen Hsieh
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May 30, 2017·The Journal of Infection·Xiaoshan LiPingmin Wei
May 21, 2010·PLoS Pathogens·Hui LiGeorge M Shaw
Feb 22, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yen-Ju ChenYi-Ming Arthur Chen
Nov 10, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rebecca A OyomopitoUNKNOWN TREAT Asia Studies to Evaluate Resistance (TASER) and The TREAT Asia HIV Observational Database

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