Molecular epidemiology of HIV type 1 in Mexico: emergence of BG and BF intersubtype recombinants

AIDS Research and Human Retroviruses
Eduardo Vázquez-VallsBlanca Miriam Torres-Mendoza

Abstract

The molecular epidemiology of subtypes and intersubtype recombinants (IRs) of human immunodeficiency virus type 1 (HIV-1) in Mexico has not been characterized fully. Understanding its regional distribution, prevalence, adaptability, viral fitness, pathogenicity, and immunogenicity is decisive for any design of an effective HIV vaccine. The aim of this study was to describe the presence of IRs types BG and BF in a Mexican population. Protease and reverse transcriptase regions of the pol gene were sequenced using an automated sequencing system. A phylogenic tree was constructed and genetic distances were calculated using MEGA 3.1. Recombination analysis was done by bootscan using SimPlot software. Two hundred and twenty-three HIV-1-positive individuals were enrolled in the study. At baseline, the mean plasma viral load was 285,500 HIV-1 RNA copies/ml and the mean CD4 cell count was 213 cells/ml. Subtype B was found in 220 (98.6%) samples, whereas IRs were found in three patients (1.4%): two (0.9%) with BG and one (0.45%) with BF. IRs were observed in 2/124 (1.6%) samples from treated patients and in 1/99 (1.0%) from naive patients. The presence of these HIV forms at low frequency points to the need for research on the diversity, ...Continue Reading

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Citations

Nov 24, 2011·PloS One·Santiago Avila-RíosUNKNOWN Mexican HIV Molecular Epidemiology Project Group
Apr 6, 2018·AIDS Research and Human Retroviruses·Pedro Gerardo Hernandez-SanchezChristian Alberto Garcia-Sepulveda

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Datasets Mentioned

BETA
M19921

Methods Mentioned

BETA
flow cytometry

Software Mentioned

SPSS
GeneLibrarian
SimPlot
Clustal W
Mega
ClustalW
bootscan

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