Molecular epidemiology of influenza A(H3N2) virus reinfections

The Journal of Infectious Diseases
Catherine B SmithW Paul Glezen

Abstract

Between 1979 and 1989, families enrolled in the Houston Family Study were prospectively monitored for influenza virus infections. Reinfection with the H3N2 subtype occurred in a number of family members, and 6 pairs of isolates (interval between collection of first and second isolate, 2-5 years) were available for molecular analysis. Changes in the hemagglutinin genes of pairs of viruses isolated from the same individuals were examined to determine the molecular basis for reinfection. The findings of this study indicate that reinfection of an individual by viruses of the same subtype may occur within a relatively short period of time when the paired strains have genetically distinct hemagglutinin genes in which amino acid changes are present in the defined antigenic sites.

Citations

Mar 28, 2003·Nature·Neil M FergusonRobin M Bush
Apr 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mario ReckerSunetra Gupta
Jun 25, 2009·Journal of Medical Virology·Sheng-Fan WangYi-Ming Arthur Chen

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