Molecular epidemiology of invasive Candida albicans at a tertiary hospital in northern Taiwan from 2003 to 2011

Medical Mycology
Shao-Hung WangJang-Jih Lu

Abstract

Candida albicans is a common cause of bloodstream fungal infections in hospitalized patients. To investigate its epidemiology, multilocus sequence typing (MLST) was performed on 285 C. albicans bloodstream isolates from patients in Chang Gung Memorial Hospital at Linkou (CGMHL), Taiwan from 2003 to 2011. Among these isolates, the three major diploid sequence types (DSTs) were 693, 659, and 443 with 19, 16, and 13 isolates, respectively. The 179 DSTs were classified into 16 clades by unweighted pair-group method using arithmetic averages (UPGMA). The major ones were clades 1, 4, 3, and 17 (54, 49, 31, and 31 isolates, respectively). Further analyses with eBURST clustered the 285 isolates into 28 clonal complexes (CC). The most common complexes were CC8, CC20, and CC9. DST 693 that had the highest number of isolates was determined to be the cluster founder of CC20, which belonged to clade 3. So far, 33 isolates worldwide including 29 from Taiwan and 4 from Korea, are CC20, suggesting that CC20 is an Asian cluster. Two fluconazole-resistant isolates belonging to CC12 and CC19 were detected. All other CGMHL isolates were susceptible to 5-flucytosine, amphotericin B, anidulfungin, caspofungin, fluconazole, itraconazole, micafungin, ...Continue Reading

References

Jul 1, 1995·The Journal of Burn Care & Rehabilitation·R L SheridanR G Tompkins
Jul 1, 1997·Clinical Microbiology Reviews·O Lortholary, B Dupont
Mar 30, 2002·Journal of Clinical Microbiology·M-E BougnouxC d'Enfert
Nov 8, 2003·Journal of Clinical Microbiology·M-E BougnouxF C Odds
Feb 6, 2004·Diagnostic Microbiology and Infectious Disease·Ming-Fang ChengHsiu-Jung Lo
Sep 29, 2004·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Marie-Elisabeth BougnouxChristophe d'Enfert
Apr 9, 2005·BMC Infectious Diseases·Ming-Fang ChengHsiu-Jung Lo
Nov 8, 2005·Journal of Clinical Microbiology·Arianna TavantiFrank C Odds
Jun 8, 2006·Journal of Clinical Microbiology·Kuo-Wei ChenShu-Ying Li
Jan 16, 2007·Clinical Microbiology Reviews·M A Pfaller, D J Diekema
Apr 10, 2007·Eukaryotic Cell·Frank C OddsChristophe d'Enfert
Sep 18, 2008·Medical Mycology·Vasilios PyrgosShmuel Shoham
Dec 18, 2008·Journal of Negative Results in Biomedicine·Yun-Liang YangHsiu-Jung Lo
Jan 20, 2009·Eukaryotic Cell·Donna M MacCallumFrank C Odds
Jun 12, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Sheng-Yuan Ruan, Po-Ren Hsueh
Dec 22, 2009·Future Microbiology·Frank C Odds
Sep 27, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Liang-Yu ChenFu-Der Wang
Dec 14, 2012·The Journal of Antimicrobial Chemotherapy·Francesco Giuseppe De RosaMario Tumbarello
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Nov 26, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Brenda A McManus, David C Coleman

❮ Previous
Next ❯

Citations

Nov 7, 2017·Frontiers in Microbiology·Camilla SekseJianxin Shi
Jul 2, 2019·Frontiers in Microbiology·Linh Thi Truc PhamPopchai Ngamskulrungroj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.