Molecular Epidemiology of Multidrug-Resistant Bacteria Isolated from Libyan and Syrian Patients with War Injuries in Two Bundeswehr Hospitals in Germany

European Journal of Microbiology & Immunology
Hagen FrickmannBernd Kreikemeyer

Abstract

We assessed the molecular epidemiology of multidrug-resistant bacteria colonizing or infecting war-injured patients from Libya and Syria who were treated at the Bundeswehr hospitals Hamburg and Westerstede, Germany. Enterobacteriaceae and Gram-negative rod-shaped nonfermentative bacteria with resistance against third-generation methoxyimino cephalosporins or carbapenems as well as methicillin-resistant Staphylococcus aureus (MRSA) from war-injured patients from Libya and Syria were assessed by molecular typing, i.e., spa typing for MRSA strains and rep-PCR and next-generation sequencing (NGS) for Gram-negative isolates. A total of 66 isolates were assessed - comprising 44 Enterobacteriaceae, 16 nonfermentative rod-shaped bacteria, and 6 MRSA from 22 patients - and 8 strains from an assessment of the patient environment comprising 5 Enterobacteriaceae and 3 nonfermentative rod-shaped bacteria. Although 24 out of 66 patient strains were isolated more than 3 days after hospital admission, molecular typing suggested only 7 likely transmission events in the hospitals. Identified clonal clusters primarily suggested transmission events in the country of origin or during the medical evacuation flights. Nosocomial transmissions in hospi...Continue Reading

Citations

Sep 13, 2019·Journal of Wound Care·Mark G RipponSamantha Westgate
Apr 11, 2019·European Journal of Microbiology & Immunology·Hans KollendaMohamed Ben Moussa
Jul 6, 2021·Future Microbiology·Marwan OsmanMonzer Hamze

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Datasets Mentioned

BETA
PRJNA407760
SRP118558

Methods Mentioned

BETA
Chip
PCRs
PCR

Software Mentioned

DiversiLab
ResFinder
Newbler assembler
BLAST
RidomStaphType
BLASTN
VITEK
Newbler
StratAirMedEvac

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