Molecular epidemiology of Mycobacterium tuberculosis in Norway

Journal of Clinical Microbiology
U R DahleD A Caugant

Abstract

The incidence of tuberculosis in Norway is one of the lowest in the world, and approximately half of the cases occur in first- and second-generation immigrants. In the present study, the genetic diversity of 92% of all strains of Mycobacterium tuberculosis isolated in Norway in 1994 to 1998 was assessed using restriction fragment length polymorphism (RFLP) analysis, with the insertion sequence IS6110 and the repetitive element DR as probes, to determine the degree of active transmission between patients. The DR probe was used as a secondary molecular marker to support or rule out clustering of strains with fewer than five copies of IS6110. After exclusion of 20 cultures representing laboratory contamination, 573 different IS6110 patterns were found among the 698 strains analyzed. Of these 573 patterns, 542 were observed only once and 31 were shared by 2 to 14 isolates. Among 81 strains (11.5%) carrying fewer than five copies of IS6110, 56 RFLP patterns were found when the results of both the IS6110 and DR methods were combined. Among the 698 strains, 570 were considered to be independent cases. A total of 14.5% of the native Norwegians and 19.7% of the foreign patients were part of a cluster. Thus, the degree of recent transmis...Continue Reading

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Citations

Feb 20, 2004·Diagnostic Microbiology and Infectious Disease·N Vijaya BhanuPradeep Seth
Dec 12, 2003·The Journal of Infection·Tony Walls, Delane Shingadia
Jun 8, 2012·Journal of Clinical Microbiology·Z Kamper-JørgensenT Lillebaek
May 31, 2002·Journal of Clinical Microbiology·Olga S ToungoussovaDominique A Caugant
Jan 9, 2003·Journal of Clinical Microbiology·Ulf R DahleDominique A Caugant
Jul 5, 2003·Journal of Clinical Microbiology·Ulf R DahleDominique A Caugant
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