Molecular epidemiology of Mycobacterium tuberculosis in western Sweden

Journal of Clinical Microbiology
Karine BrudeyNalin Rastogi

Abstract

The genetic diversity of Mycobacterium tuberculosis isolates among patients from Sweden was determined by a combination of two PCR-based techniques (spoligotyping and variable number of tandem repeats analysis). It resulted in a clustering of 23.6% of the isolates and a rate of recent transmission of 14.1%. The clustered isolates mainly belonged to the Haarlem family (23.2%), followed by the Beijing (9.8%), Latin American and Mediterranean (LAM; 8%), and East African-Indian (EAI; 6.2%) families. A comparison of the spoligotypes with those in the international spoligotyping database showed that 62.5% of the clustered isolates and 36.6% of all isolates typed were grouped into six major shared types. A comparison of the spoligotypes with those in databases for Scandinavian countries showed that 33% of the isolates belonged to an ill-defined T family, followed by the EAI (22%), Haarlem (20%), LAM (11%), Central Asian (5%), X (5%), and Beijing (4%) families. Both the highest number of cases and the proportion of clustered cases were observed in patients ages 15 to 39 years. Nearly 10% of the isolates were resistant to one or more drugs (essentially limited to isoniazid monoresistance). However, none of the strains were multidrug res...Continue Reading

References

May 1, 1981·Journal of Clinical Microbiology·S H SiddiqiG Middlebrook
Aug 1, 1995·Journal of Clinical Microbiology·Z H YangA B Andersen
Dec 1, 1995·Journal of Clinical Microbiology·D van SoolingenJ D van Embden
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·S SreevatsanJ M Musser
Aug 1, 1997·Tropical Medicine & International Health : TM & IH·D WilkinsonA W Sturm
Jun 5, 1998·Microbiology·Richard Frothingham, Winifred A Meeker-O'Connell
Aug 7, 1999·The Journal of Infectious Diseases·D van SoolingenJ D van Embden
Aug 30, 2001·Journal of Clinical Microbiology·A KrüünerG Källenius
May 31, 2002·Journal of Clinical Microbiology·Olga S ToungoussovaDominique A Caugant
Jul 27, 2002·Emerging Infectious Diseases·Judith R GlynnDick van Soolingen
Nov 26, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P MoströmN Rastogi
Jan 9, 2003·Journal of Clinical Microbiology·Ulf R DahleDominique A Caugant
Apr 19, 2003·Journal of Clinical Microbiology·Kirsi PuustinenHanna Soini
Jul 5, 2003·Journal of Clinical Microbiology·Ulf R DahleDominique A Caugant
Nov 12, 2003·Emerging Infectious Diseases·Martien W BorgdorffDick van Soolingen

❮ Previous
Next ❯

Citations

Apr 27, 2007·Journal of Clinical Microbiology·Nicoletta LariCarlo Garzelli
Mar 29, 2011·BMC Infectious Diseases·Maya A DymovaMaxim L Filipenko
Jan 5, 2014·PloS One·Pieter Willem SmitHanna Soini
May 18, 2006·Emerging Infectious Diseases·UNKNOWN European Concerted Action on New Generation Genetic Markers and Techniques for the Epidemiology and Control of Tuberculosis
Oct 12, 2013·The European Respiratory Journal·Andreas SandgrenEnrico Girardi
Jun 4, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Tewodros DebebeGobena Ameni
Feb 14, 2012·The Journal of Infection·Ewa Augustynowicz-KopećZofia Zwolska
Jul 3, 2015·Epidemiology and Infection·P E RäisänenO Lyytikäinen
Sep 10, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E SvenssonUNKNOWN Western Sweden Tuberculosis Epidemiology Study Group
Apr 28, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Riza DurmazNalin Rastogi
Feb 24, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Urvashi Balbir SinghJitendra Nath Pande
Nov 2, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Carlo Garzelli, Laura Rindi
Sep 20, 2008·FEMS Immunology and Medical Microbiology·Igor MokrousovNalin Rastogi
Aug 19, 2007·Scandinavian Journal of Infectious Diseases·Harald FjällbrantLars Olof Larsson
Aug 29, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mohammad Khaja Mafij UddinSayera Banu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.