Molecular epidemiology of norovirus infections in children and adults: sequence analysis of region C indicates genetic diversity of NVGII strains in Kolkata, India

Epidemiology and Infection
S M NatarajuT Krishnan

Abstract

Faecal specimens of diarrhoea cases (n=2495, collected between November 2007 and October 2009) from Infectious Diseases and Beliaghata General (ID&BG) Hospital, Kolkata, India, were screened by RT-PCR using specific primers targeting region C of the capsid gene of noroviruses (NoVs) to determine the seasonal distribution and clinical characteristics of NoVs associated with diarrhoea. NoV infection was detected in 78 cases, mostly in children aged <2 years. In 22/78 positive cases, the virus was detected as the sole agent; others were as mixed infections with other enteric pathogens. Sequencing of NVGII strains showed clustering with GII.4 NoVs followed by GII.13 and GII.6 NoVs. Clinical characteristics of the diarrhoeic children and adults in Kolkata indicated that NoV infections were detected throughout the year and were associated with a mild degree of dehydration.

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Citations

Mar 1, 2012·Virology Journal·Fabián Gómez-SantiagoHerlinda García-Lozano
Dec 12, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·T N Hoa TranOsamu Nakagomi
Jul 16, 2015·Journal of Medical Virology·Amna AlamAnita Zaidi
Dec 17, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Thi Nguyen Hoa-TranOsamu Nakagomi
Nov 28, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Ruta KulkarniShobha D Chitambar
Sep 26, 2013·The American Journal of Tropical Medicine and Hygiene·Vipin Kumar MenonGagandeep Kang

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