Molecular epidemiology of pathogenic Leptospira spp. in the straw-colored fruit bat (Eidolon helvum) migrating to Zambia from the Democratic Republic of Congo

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Hirohito OgawaHirofumi Sawa

Abstract

The role played by bats as a potential source of transmission of Leptospira spp. to humans is poorly understood, despite various pathogenic Leptospira spp. being identified in these mammals. Here, we investigated the prevalence and diversity of pathogenic Leptospira spp. that infect the straw-colored fruit bat (Eidolon helvum). We captured this bat species, which is widely distributed in Africa, in Zambia during 2008-2013. We detected the flagellin B gene (flaB) from pathogenic Leptospira spp. in kidney samples from 79 of 529 E. helvum (14.9%) bats. Phylogenetic analysis of 70 flaB fragments amplified from E. helvum samples and previously reported sequences, revealed that 12 of the fragments grouped with Leptospira borgpetersenii and Leptospira kirschneri; however, the remaining 58 flaB fragments appeared not to be associated with any reported species. Additionally, the 16S ribosomal RNA gene (rrs) amplified from 27 randomly chosen flaB-positive samples was compared with previously reported sequences, including bat-derived Leptospira spp. All 27 rrs fragments clustered into a pathogenic group. Eight fragments were located in unique branches, the other 19 fragments were closely related to Leptospira spp. detected in bats. These ...Continue Reading

References

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Citations

Oct 6, 2015·PLoS Neglected Tropical Diseases·Gauthier DobignyEric Bertherat
Nov 13, 2015·PLoS Pathogens·Muriel DietrichWanda Markotter
Jan 11, 2018·Transboundary and Emerging Diseases·G G Ballados-GonzálezA Cruz-Romero
Mar 11, 2020·Vector Borne and Zoonotic Diseases·Xiao-Juan MaXue-Jie Yu
May 19, 2018·Emerging Infectious Diseases·Hui-Ju HanXue-Jie Yu
Jul 19, 2017·Parasitology·Vanina GuernierCyrille Goarant
Feb 3, 2021·Transboundary and Emerging Diseases·Veronika SeidlovaJan Zukal

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Methods Mentioned

BETA
PCR

Software Mentioned

Clustal W
MEGA

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