Molecular epidemiology of rotavirus gastroenteritis in Japan during 2014-2015: Characterization of re-emerging G2P[4] after rotavirus vaccine introduction

Journal of Medical Virology
Nusrat KhandokerHiroshi Ushijima

Abstract

Rotavirus vaccines have been available in Japan since 2011. This study conducted to monitor the trend of group A rotavirus (RVA) genotypes 3 years after vaccine introduction. A total of, 539 fecal samples were collected from children with acute gastroenteritis in six regions during July 2014-June 2015. Among them, 178 samples (33.0%) were positive for RVA. The most predominant genotype was G1P[8] (35.9%) followed by G2P[4] (26.4%), G9P[8] (21.3%), G3P[8] (4.5%), and G3P[9] (4.5%). The detection rate of G2P[4] was increased soon after vaccine introduction. Sequence analyses of VP7 and VP4 genes of the representative G2P[4] strains were found to be clustered in sub-lineage IVa of lineage IV. It is noteworthy that one amino acid substitution in the antigenic epitope (Q114P) of VP4 gene was found in representative G2P[4] strains of the current study. However, it is unclear whether the change in antigenic epitope is due to the effect of vaccination or due to natural variation, warranting further continuous monitoring of rotavirus evolution after vaccine introduction.

References

Jun 1, 1992·Journal of Clinical Microbiology·J R GentschM K Bhan
Sep 1, 1997·Nucleic Acids Research·S F AltschulD J Lipman
Feb 6, 2010·The Pediatric Infectious Disease Journal·Shuvra K DeyYoshimi Ota
Nov 6, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Aksara ThongprachumHiroshi Ushijima
Sep 12, 2013·PloS One·Claudio F LanataUNKNOWN Child Health Epidemiology Reference Group of the World Health Organization and UNICEF
Oct 1, 2013·The Journal of General Virology·Giovanni M GiammancoSimona De Grazia
Mar 13, 2014·Journal of Medical Virology·Dioselina Peláez-CarvajalManish Patel
Sep 17, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Renáta DóróKrisztián Bányai
Sep 23, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mariela Martínez GómezJosé Paulo Gagliardi Leite
Oct 5, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Fang-Tzy WuHo-Sheng Wu
Apr 17, 2015·Journal of Medical Virology·Aksara ThongprachumHiroshi Ushijima
Jun 1, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yen Hai DoanOsamu Nakagomi
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
Nov 15, 2016·Future Virology·Eleanor BurnettUmesh D Parashar

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Citations

Jul 19, 2019·Communicable Diseases Intelligence·Susie Roczo-FarkasUNKNOWN the Australian Rotavirus Surveillance Group
May 5, 2020·The Journal of Infectious Diseases·Ignacio Salamanca de la CuevaUNKNOWN Rota-081 Study Group

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