Molecular epidemiology of serotype O foot-and-mouth disease virus isolated from cattle in Ethiopia between 1979-2001

The Onderstepoort Journal of Veterinary Research
M SahleW Vosloo

Abstract

Partial 1D gene characterization was used to study phylogenetic relationships between 17 serotype O foot-and-mouth disease (FMD) viruses in Ethiopia as well as with other O-type isolates from Eritrea, Kenya, South and West Africa, the Middle East, Asia and South America. A homologous region of 495 bp corresponding to the C-terminus end of the 1D gene was used for phylogenetic analysis. This study described three lineages, viz. African/Middle East-Asia, Cathay and South American. Within lineage I, three topotypes were defined, viz. East and West Africa and the Middle East-Asia together with the South African isolate. The Ethiopian isolates clustered as part of topotype I, the East African topotype. Two clades (based on < 12 % nucleotide difference) A and B were identified within the East African isolates, with clade A being further classified into three significant branches, A1 (80% bootstrap support), A2 (89% bootstrap support) and A3 (94% bootstrap support). Clade B consisted of two Kenyan isolates. Within topotype I, the 17 Ethiopian isolates showed genetic heterogeneity between themselves with sequence differences ranging from 4.6-14 %. Lineage 2 and 3 could be equated to two significant topotypes, viz. Cathay and South Amer...Continue Reading

Citations

Aug 19, 2010·Tropical Animal Health and Production·Haileleul NegusssieShiferaw Jenberie
Oct 1, 2009·Emerging Infectious Diseases·Gelagay AyeletNick J Knowles
Jul 24, 2014·Transboundary and Emerging Diseases·T TekleghiorghisA Dekker
Dec 23, 2008·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Joern Klein
Nov 1, 2015·Transboundary and Emerging Diseases·T TekleghiorghisA Dekker
Jun 24, 2020·Transboundary and Emerging Diseases·Daniel GizawDonald P King

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