Molecular epidemiology of Streptococcus pneumoniae with decreased susceptibility to penicillin in a Paris children's hospital.

Journal of Clinical Microbiology
D MoissenetH Vu-Thien

Abstract

Among pneumococci with decreased susceptibility or pneumococci resistant to penicillin (PRP) isolated at Armand-Trousseau children's hospital, those expressing capsular serotypes 23F, 9V, and 14 were the most frequently isolated. We compared 53 clinical isolates (14 type 9V, 26 type 23F, and 13 type 14) by analysis of chromosomal macrorestriction patterns and DNA restriction patterns of the penicillin-binding protein (PBP) genes pbp 2b, pbp 2x, and pbp 1a. All 9V isolates originated from the same clone. Five 23F clones were distinguished, the largest of which comprised 20 isolates. The main type 14 clone comprised nine isolates; three other type 14 strains were closely related to the 9V clone, probably by horizontal transfer of capsular biosynthesis genes. Most 23F and type 14 isolates shared the same PBP gene restriction patterns as the 9V clone, suggesting horizontal transfer of altered PBP genes.

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Citations

Jul 10, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·R B RobertsUNKNOWN PRP Collaborative Study Group
Jul 10, 2001·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·M C VelaE Castañeda
Nov 18, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·E CastañedaA Tomasz
Nov 18, 1998·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·A RossiA Tomasz
Jul 11, 1998·Journal of Clinical Pathology·L M Hall
Aug 23, 2006·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·B SenerO Eser
Oct 31, 1998·Antimicrobial Agents and Chemotherapy·G A PankuchP C Appelbaum
May 1, 1999·Antimicrobial Agents and Chemotherapy·T A DaviesP C Appelbaum
Feb 13, 1999·Journal of Clinical Microbiology·L Setchanova, A Tomasz

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