Molecular epidemiology of the Bacillus anthracis isolates collected throughout Turkey from 1983 to 2011.

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Riza DurmazAnthrax Study Group

Abstract

The main perspective of this study was to determine cross-transmissions amongst anthrax cases and provide detailed information regarding the genotypes of Bacillus anthracis isolates circulating in Turkey. A total of 251 B. anthracis isolates were obtained from human (93 isolates), animal (155 isolates), and environmental (three isolates) samples in various provinces of Turkey. All isolates were susceptible to quinolones, vancomycin, tigecycline, and linezolid, but not to ceftriaxone. Excluding human isolates, one of the animal isolates was found to be resistant to penicillin, erythromycin, and doxycycline. Multiple-locus variable-number tandem repeats analysis including 8 loci (MLVA8) revealed 12 genotypes, in which genotype 43 was observed at the highest frequency (41.8 %), followed by genotype 35 (25.5 %) and genotype 27 (10.4 %). Major subtype A3.a was the predominant cluster, including 86.8 % of the isolates. The MLVA25 analysis for the 251 isolates yielded 62 different genotypes, 33 of which had only one isolate, while the remaining 29 genotypes had 2 to 43 isolates, with a total of 218 isolates (86.9 %). These findings indicate very high cross-transmission rates within anthrax cases in Turkey. The genotypes diagnosed in T...Continue Reading

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Citations

Nov 6, 2013·Biosecurity and Bioterrorism : Biodefense Strategy, Practice, and Science·Sylviane Derzelle, Simon Thierry
Jan 23, 2014·Emerging Infectious Diseases·Katherine A HendricksUNKNOWN Workgroup on Anthrax Clinical Guidelines
Jul 15, 2015·Tropical Animal Health and Production·Amin Abdelfattah AqelAntonio Fasanella
Aug 14, 2013·Letters in Applied Microbiology·W Beyer, P C B Turnbull
Oct 23, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Farzana Islam RumeMatthias Hanczaruk
Apr 2, 2015·Expert Review of Anti-infective Therapy·Stephanie Ascough, Daniel Martin Altmann

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