PMID: 9531663Jun 13, 1998Paper

Molecular epidemiology of tuberculosis in Prague: analysis by restriction fragment length polymorphism

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
M KubínA Kocová

Abstract

To characterize by restriction fragment length polymorphism (RFLP) patterns, the distribution of different Mycobacterium tuberculosis strains isolated consecutively from 75 tuberculosis patients who resided in Prague and had culture-confirmed cases during a 4-month period in 1995. The insertion sequence IS6110-based RFLP analysis of M. tuberculosis isolates was carried out. There were a total of 75 patients with various forms of tuberculosis (54 males; 21 females). The sources of M. tuberculosis isolates were sputum (n = 64), pleura or lymph node drainage (n = 8), and urine (n = 3). Fifty-three of the patients (70.7%) had isolates with unique RFLP patterns, while 22 (29.3%) had isolates that belonged to seven clusters of related RFLP patterns. The seven clusters consisted of four groups of two patients, two groups of four patients, and one group of six patients. Most of the patients whose isolates fell within a clustered RFLP pattern lived in different quarters of the city and had no identifiable contacts with other patients whose isolates had the same pattern. The finding that isolates from most patients (70.7%) had unique rather than clustered RFLP patterns suggests that endogenous reactivation rather than exogenous transmiss...Continue Reading

References

Jul 1, 1995·American Journal of Respiratory and Critical Care Medicine·C R FriedmanL W Riley
Dec 1, 1994·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M C RaviglioneA Kochi

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Citations

Nov 29, 2001·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·J MagnaniUNKNOWN TBNetwork
Dec 25, 2015·Archives of Disease in Childhood·Megan DelisleDorothy L Moore
Nov 24, 2007·Journal of Medical Microbiology·Liselotte AristimuñoSofía Samper
Sep 6, 2003·Journal of Clinical Microbiology·Dragana VukovićStefan Niemann

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