Molecular epidemiology of urinary tract isolates of vancomycin-resistant Enterococcus faecium from North America

International Journal of Antimicrobial Agents
Kimberly A NicholGeorge G Zhanel

Abstract

Vancomycin-resistant Enterococcus faecium (VRE) are a common cause of nosocomial infections and are important agents of gastrointestinal colonisation. As the prevalence of VRE in hospitalised patients continues to increase, implementation of appropriate infection control measures requires routine surveillance of VRE transmission patterns. The purpose of the present study was to investigate the molecular epidemiology of VRE isolates within the USA and Canada. Two hundred and eighty-three urinary tract isolates of VRE were collected in the year 2000 from ten Canadian hospitals and 28 US tertiary care medical centres representing seven of the nine geographic regions of the United States Bureau of the Census. The in vitro activity of vancomycin, teicoplanin and nine comparators was determined by broth microdilution. The genetic relatedness among isolates was evaluated by pulsed-field gel electrophoresis (PFGE). Resistance rates (intermediate and resistant) were 100% for vancomycin and 78.7% for teicoplanin. Resistance was lowest with linezolid, chloramphenicol and nitrofurantoin at 0.3%, 0.3% and 0.5%, respectively. PFGE revealed that genetic heterogeneity amongst isolates from each of the medical centres varied considerably. Despi...Continue Reading

Citations

Apr 6, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E SadowyW Hryniewicz
Nov 10, 2009·Future Microbiology·Rob Jl Willems, Willem van Schaik
Dec 17, 2009·International Journal of Antimicrobial Agents·Guido WernerWolfgang Witte
Oct 27, 2010·Pharmacotherapy·Brett H HeintzCinda L Christensen
Dec 8, 2015·Journal of Global Antimicrobial Resistance·Ali AlawiehFadi A Zaraket
Jan 26, 2008·Journal of Dairy Science·C S Petersson-WolfeJ S Hogan
Jul 5, 2007·Current Opinion in Infectious Diseases·Rob J L Willems, Marc J M Bonten
Jan 8, 2014·Expert Review of Anti-infective Therapy·Rok ČivljakNicola Petrosillo
May 27, 2010·Journal of Food Protection·R P CordeiroR A Holley

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