PMID: 6413394Jan 1, 1983Paper

Molecular events in the processing of avidin by antigen-presenting cells (APC). III. Activation of T-lymphocyte lines and H-2 restriction are mediated by processed avidin associated with I-region gene products

Immunogenetics
A FriedmanI R Cohen

Abstract

We investigated the interaction between processed avidin (PA) and avidin-specific lines of T lymphocytes free of resident antigen-presenting cells (APC). We found that PA was able to replace the requirement for APC in the T-lymphocyte proliferative assay, only if the PA was associated with an Ia-positive moiety (IPM) supplied by the APC. In addition to supplying a necessary signal for a proliferative response to PA, IPM imposed H-2 restriction on the PA molecule. The association between PA and IPM was reversible and the two moieties could be physically separated and recombined. The results support a conclusion that major histocompatibility restriction of the interaction between T lymphocytes and APC is due to the association between processed antigen and an APC element containing I-region products.

References

Jan 1, 1978·Immunological Reviews·B Benacerraf, R N Germain
Jan 1, 1978·Immunological Reviews·E E SercarzL Adorini
Jan 1, 1978·Scandinavian Journal of Immunology·R H Schwartz
Jan 1, 1979·Journal of Immunological Methods·K C LeeM Wong
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·I R CohenA Ben-Nun
Jan 1, 1975·Advances in Protein Chemistry·N M Green
Aug 1, 1980·European Journal of Immunology·Z Grossman, I R Cohen
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Feb 1, 1982·Immunology Today·E Shevach
Feb 1, 1982·Immunology Today·A S Rosenthal

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Citations

Aug 1, 1987·Immunological Reviews·S BuusH M Grey
Apr 1, 1993·European Journal of Immunology·D Melamed, A Friedman
Aug 1, 1990·Immunological Investigations·R M Chau, A S Lau
Jan 1, 1984·Immunogenetics·A Friedman, I R Cohen
Nov 13, 1991·Biochimica Et Biophysica Acta·A R Beaudoin, G Grondin

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